Journal article
Isolation and plasmid characterization of carbapenemase (IMP-4) producing Salmonella enterica Typhimurium from cats
Scientific Reports, Vol.6, Article 35527
2016
Abstract
Carbapenem-resistant Enterobacteriaceae (CRE) are a pressing public health issue due to limited therapeutic options to treat such infections. CREs have been predominantly isolated from humans and environmental samples and they are rarely reported among companion animals. In this study we report on the isolation and plasmid characterization of carbapenemase (IMP-4) producing Salmonella enterica Typhimurium from a companion animal. Carbapenemase-producing S. enterica Typhimurium carrying bla IMP-4 was identified from a systemically unwell (index) cat and three additional cats at an animal shelter. All isolates were identical and belonged to ST19. Genome sequencing revealed the acquisition of a multidrug-resistant IncHI2 plasmid (pIMP4-SEM1) that encoded resistance to nine antimicrobial classes including carbapenems and carried the bla IMP-4-qacG-aacA4-catB3 cassette array. The plasmid also encoded resistance to arsenic (MIC-150 mM). Comparative analysis revealed that the plasmid pIMP4-SEM1 showed greatest similarity to two bla IMP-8 carrying IncHI2 plasmids from Enterobacter spp. isolated from humans in China. This is the first report of CRE carrying a bla IMP-4 gene causing a clinical infection in a companion animal, with presumed nosocomial spread. This study illustrates the broader community risk entailed in escalating CRE transmission within a zoonotic species such as Salmonella, and in a cycle that encompasses humans, animals and the environment.
Details
- Title
- Isolation and plasmid characterization of carbapenemase (IMP-4) producing Salmonella enterica Typhimurium from cats
- Authors/Creators
- S. Abraham (Author/Creator) - Murdoch UniversityM. O’Dea (Author/Creator) - Murdoch UniversityD.J. Trott (Author/Creator) - The University of AdelaideR.J. Abraham (Author/Creator) - The University of AdelaideD. Hughes (Author/Creator) - Veterinary Medical CenterS. Pang (Author/Creator) - Murdoch UniversityG. McKew (Author/Creator) - Concord Repatriation General HospitalE.Y.L. Cheong (Author/Creator) - Concord Repatriation General HospitalJ. Merlino (Author/Creator) - Concord Repatriation General HospitalS. Saputra (Author/Creator) - The University of AdelaideR. Malik (Author/Creator) - The University of SydneyT. Gottlieb (Author/Creator) - Concord Repatriation General Hospital
- Publication Details
- Scientific Reports, Vol.6, Article 35527
- Publisher
- Nature Publishing Group
- Identifiers
- 991005542614007891
- Copyright
- © 2016 The Author(s)
- Murdoch Affiliation
- School of Veterinary and Life Sciences
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
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- Citation topics
- 1 Clinical & Life Sciences
- 1.23 Antibiotics & Antimicrobials
- 1.23.146 Antimicrobial Resistance
- Web Of Science research areas
- Microbiology
- ESI research areas
- Pharmacology & Toxicology