Journal article
Jekyll and Hyde: Evolving perspectives on the function and potential of the adult liver progenitor (oval) cell
BioEssays, Vol.27(11), pp.1192-1202
2005
Abstract
The liver progenitor cell (LPC) has enormous potential for use in cell therapy to treat liver disease. Since liver regenerates readily from pre-existing hepatocytes, a role for LPCs and, indeed, their existence have been questioned. Research during the last decade has established that LPCs are an important alternative source of cells for liver regeneration. Their utility for cell therapy lies in their ability to generate both hepatocytes and cholangiocytes. However, they are observed in liver diseases that often lead to cancer and there is experimental evidence that implicates LPCs as the source of tumours. This article provides a brief history of the studies that established the functional importance of LPCs in liver disease. It focuses on mouse models that have led to the identification of factors that regulate LPC growth and differentiation and discusses LPCs derived from different sources. Recent promising results from both in vitro and vivo studies suggest that LPCs could be useful for cell therapy. In the context of liver disease, LPCs may indeed be the cell of the future and understandably “our favourite cell”.
Details
- Title
- Jekyll and Hyde: Evolving perspectives on the function and potential of the adult liver progenitor (oval) cell
- Authors/Creators
- B. Knight (Author/Creator)V.B. Matthews (Author/Creator)J.K. Olynyk (Author/Creator)G.C. Yeoh (Author/Creator)
- Publication Details
- BioEssays, Vol.27(11), pp.1192-1202
- Publisher
- John Wiley & Sons Inc.
- Identifiers
- 991005545285907891
- Copyright
- © 2005 Wiley Periodicals, Inc.
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- Citation topics
- 1 Clinical & Life Sciences
- 1.102 Stem Cell Research
- 1.102.1150 Hepatocyte Growth Factor
- Web Of Science research areas
- Biochemistry & Molecular Biology
- Biology
- ESI research areas
- Biology & Biochemistry