Kaat koort: Study protocol for a pragmatic randomized controlled trial of a multifactorial, multidisciplinary Aboriginal Health Practitioner-led Aboriginal dementia prevention intervention

Carrington CJ Shepherd; Melissa A. Dunham; Lina Gubhaju; Karen E. Lamb; Digsu N. Koye; Phoebe Fitzpatrick; Emily Banks; Kaarin J. Anstey; Melinda Carrington; Daniel McAullay; Ofra Kalter-Leibovici; Grace Joshy; Lesley Nelson; Jason Agostino; Ellie Paige; Kathleen Abu-Saad; Elise Alexander; Rona MacNiven; Kelsey Griffen; Fiona Collins; Salena Linforth-Milham; Dolores Gilbert; Cindy Prior; Sadia Rind; Richelle Douglas; Sandra Eades

doi:10.1016/j.conctc.2025.101457

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Kaat koort: Study protocol for a pragmatic randomized controlled trial of a multifactorial, multidisciplinary Aboriginal Health Practitioner-led Aboriginal dementia prevention intervention

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Kaat koort: Study protocol for a pragmatic randomized controlled trial of a multifactorial, multidisciplinary Aboriginal Health Practitioner-led Aboriginal dementia prevention intervention

Carrington CJ Shepherd, Melissa A. Dunham, Lina Gubhaju, Karen E. Lamb, Digsu N. Koye, Phoebe Fitzpatrick, Emily Banks, Kaarin J. Anstey, Melinda Carrington, Daniel McAullay, …

Contemporary clinical trials communications, Vol.44, 101457

2025

DOI: https://doi.org/10.1016/j.conctc.2025.101457

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Abstract

Aboriginal/Torres Strait Islander peoples

Blood pressure

Cardiovascular disease

Cognitive decline

Dementia

Indigenous

Randomized controlled trial

Background Limited available data indicate that dementia prevalence rates among Aboriginal and Torres Strait Islander (hereafter Aboriginal) peoples are 3–5 times higher than the overall Australian population. Effective, pragmatic and scalable interventions are urgently required to address this disproportionate burden of dementia in Aboriginal populations. Methods Kaat Koort is a pragmatic two-arm parallel-group randomized controlled trial which will recruit a sample of 354 participants from two Aboriginal community-controlled health services in the south-west of Western Australia. Eligible participants are aged 35–60 years with risk factors for cardiovascular disease. Participants will be randomized in a 1:1 ratio to receive either a 12-month multifactorial lifestyle intervention (guided by Aboriginal Health Practitioners) that involves cardiovascular risk management, a lifestyle program targeting diet and physical activity, and support for smoking cessation and depression, or usual care (control). The primary endpoints are change in (i) systolic, and (ii) diastolic blood pressure. Secondary endpoints are changes in other cardiovascular risk factors (elevated blood pressure, HDL cholesterol, HbA1c, waist circumference, and absolute cardiovascular risk score), cognitive functioning, and adherence to Australian dietary and physical activity guidelines. Outcomes will be collected at baseline, and 6- and 12-months post-baseline. Discussion This trial aims to determine the efficacy of a multifactorial lifestyle intervention in reducing blood pressure among Aboriginal people aged 35–60 years at risk of dementia. Trial registration number ACTRN12621001022853; Australian New Zealand Clinical Trial Registry identifier.

Details

Title: Kaat koort: Study protocol for a pragmatic randomized controlled trial of a multifactorial, multidisciplinary Aboriginal Health Practitioner-led Aboriginal dementia prevention intervention
Authors/Creators: Carrington CJ Shepherd - Curtin Medical School, Curtin University, Kent Street, 6102, Bentley, Australia
Melissa A. Dunham - Curtin University
Lina Gubhaju - Baker Heart and Diabetes Institute
Karen E. Lamb - The University of Melbourne
Digsu N. Koye - The University of Melbourne
Phoebe Fitzpatrick - The University of Melbourne
Emily Banks - Australian National University
Kaarin J. Anstey - UNSW Sydney
Melinda Carrington - Baker Heart and Diabetes Institute
Daniel McAullay - The Kids Research Institute Australia
Ofra Kalter-Leibovici - Sheba Medical Center
Grace Joshy - Australian National University
Lesley Nelson - Tharawal Aboriginal
Jason Agostino - Academic Unit of General Practice, Australian National University, 0200, Canberra, Australia
Ellie Paige - National Centre for Epidemiology and Population Health, Australian National University, 62 Mills Rd, 2601, Acton, Australia
Kathleen Abu-Saad - Sheba Medical Center
Elise Alexander - Centre for Aboriginal Medical and Dental Health (CAMDH), Medical School, University of Western Australia, 35 Stirling Hwy, 6009, Crawley, Australia
Rona MacNiven - UNSW Sydney
Kelsey Griffen - UNSW Sydney
Fiona Collins - Tharawal Aboriginal
Salena Linforth-Milham - South West Aboriginal Medical Service, 51/55 Forrest Avenue, 6230, Bunbury, Australia
Dolores Gilbert - Derbarl Yerrigan Health Service, 156 Wittenoom Street, East Perth, 6004, Australia
Cindy Prior - The Kids Research Institute Australia
Sadia Rind - Derbarl Yerrigan Health Service, 156 Wittenoom Street, East Perth, 6004, Australia
Richelle Douglas - Derbarl Yerrigan Health Service, 156 Wittenoom Street, East Perth, 6004, Australia
Sandra Eades - The University of Melbourne
Publication Details: Contemporary clinical trials communications, Vol.44, 101457
Publisher: Elsevier Inc.
Number of pages: 8
Grant note: Dementia in Indigenous ship in the Cardiology Casella: APP1151848
The study was funded Council grant (APP1151848) , Dementia in Indigenous ship in the Cardiology Casella. Declaration of competing The authors declare interests or personal relationships
Identifiers: 991005743939807891
Murdoch Affiliation: Ngangk Yira Institute for Change
Language: English
Resource Type: Journal article

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