Journal article
Killer cell inhibitory receptor interactions with HLA class I molecules
Human Immunology, Vol.52(1), pp.1-11
1997
Abstract
Human killer cell inhibitory receptors (KIR) are novel members of the immunoglobulin superfamily of cell surface glycoproteins, which are expressed by lymphocytes with natural killer (NK) and cytotoxic T-cell (CTL) phenotypes. These receptors have specificity for relatively conserved epitopes of HLA-A, -B, and -C class I antigens. Recent studies have identified KIR as being involved in the transmission of negative, inhibitory signaling events to the cytotoxic cell which prevent or diminish target cell lysis. KIR are thus likely to play an important role in the responses of alloreactive NK cells and CTL to allogeneic HLA antigens. In this article, we review the known structural and functional characteristics of KIR, suggest a possible mechanism for the transmission of intracellular negative signaling by these receptors, and discuss the relevance of KIR function and HLA specificity to the clinical transplantation of allogeneic tissues.
Details
- Title
- Killer cell inhibitory receptor interactions with HLA class I molecules
- Authors/Creators
- N.T. Young (Author/Creator)M. Bunce (Author/Creator)P.J. Morris (Author/Creator)K.I. Welsh (Author/Creator)
- Publication Details
- Human Immunology, Vol.52(1), pp.1-11
- Publisher
- Elsevier BV
- Identifiers
- 991005540722607891
- Copyright
- 1997 American Society for Histocompatability and Immunogenetics
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- Citation topics
- 1 Clinical & Life Sciences
- 1.6 Immunology
- 1.6.1021 Natural Killer Cells
- Web Of Science research areas
- Immunology
- ESI research areas
- Immunology