Killer immunoglobulin-like receptors and HLA act both independently and synergistically to modify HIV disease progression

S. Gaudieri; D. DeSantis; E. McKinnon; C. Moore; D. Nolan; C.S. Witt; S.A. Mallal; F.T. Christiansen

doi:10.1038/sj.gene.6364256

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Killer immunoglobulin-like receptors and HLA act both independently and synergistically to modify HIV disease progression

Journal article

Peer reviewed

Killer immunoglobulin-like receptors and HLA act both independently and synergistically to modify HIV disease progression

S. Gaudieri, D. DeSantis, E. McKinnon, C. Moore, D. Nolan, C.S. Witt, S.A. Mallal and F.T. Christiansen

Genes and Immunity, Vol.6(8), pp.683-690

2005

DOI: https://doi.org/10.1038/sj.gene.6364256

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Abstract

Variation in the host response to infection by pathogens including HIV-1 may be conferred by polymorphic genetic factors such as HLA and killer immunoglobulin-like receptors (KIR) genes. Here, we examined KIR and HLA genotype effects on pretreatment viral load, rate of CD4+ T-cell decline and progression to AIDS among adult HIV-1-infected patients within the Western Australian HIV Study Cohort. In this study, carriage of KIR genes within the "B" haplotype (eg KIR2DS2) was specifically associated with a more rapid CD4+ T-cell decline over time and progression to AIDS. In contrast, KIR gene repertoire had no effect on pretreatment viral load while selected HLA alleles (eg HLA-B*5701, HLA-B*2705) demonstrated significant protective effects on viremia. Furthermore, interactions between specific HLA and KIR genes did appear to influence HIV disease progression. The results suggest that host genetic variation within the HLA and KIR gene complexes have clinically relevant effects on the course of HIV-1/AIDS, acting independently as well as synergistically to modify disease progression at multiple levels.

Details

Title: Killer immunoglobulin-like receptors and HLA act both independently and synergistically to modify HIV disease progression
Authors/Creators: S. Gaudieri (Author/Creator) - Royal Perth Hospital
D. DeSantis (Author/Creator) - Royal Perth Hospital
E. McKinnon (Author/Creator) - Royal Perth Hospital
C. Moore (Author/Creator) - Royal Perth Hospital
D. Nolan (Author/Creator) - Royal Perth Hospital
C.S. Witt (Author/Creator) - Royal Perth Hospital
S.A. Mallal (Author/Creator) - Royal Perth Hospital
F.T. Christiansen (Author/Creator) - Royal Perth Hospital
Publication Details: Genes and Immunity, Vol.6(8), pp.683-690
Publisher: Nature Publishing Group
Identifiers: 991005542774507891
Copyright: © 2005 Nature Publishing Group.
Murdoch Affiliation: Centre for Clinical Immunology and Biomedical Statistics
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.6 Immunology; 1.6.1021 Natural Killer Cells
Web Of Science research areas: Genetics & Heredity; Immunology
ESI research areas: Molecular Biology & Genetics