Logo image
Back
Kinetic behavior of muscle carnitine palmitoyltransferase I in the lamprey Geotria australis, before and after the marine trophic phase
Journal article   Peer reviewed

Kinetic behavior of muscle carnitine palmitoyltransferase I in the lamprey Geotria australis, before and after the marine trophic phase

M.H. Cake, G.W. Power, L.M. Stonell and I.C. Potter
The Journal of Experimental Zoology, Vol.281(1), pp.6-11
1998
DOI: https://doi.org/10.1002/(SICI)1097-010X(19980501)281:1<6::AID-JEZ2>3.0.CO;2-S
url
Link to Published Version *Subscription may be requiredView

Abstract

This study was aimed at determining whether the marked changes that occur in the diet during the life cycle of the lamprey Geotria australis, and thus also in the fatty acid composition of the triacylglycerol stores, are accompanied by alterations in the V(max) and apparent K0.5 of skeletal muscle carnitine palmitoyltransferase I (CPT I) towards the CoA derivatives of the fatty acids 16:0, 16:1n-7, 18:1n-9, 18:2n-6, and 22:6n-3. The activity of CPT I towards the last four of these acyl CoAs increased progressively from the microphagous larvae to young adults, prior to the onset of their marine trophic phase, to fully grown adults, which had ceased feeding or fish and embarked on their spawning run. For example, the V(max) of CPT I towards 18:1n-9 rose from 4.4, to 7.6 to 11.5 nmol · min-1 · mg mitochondrial protein-1 over the course of the three life-cycle stages. The values for the V(max) of lamprey muscle CPT I towards the various CoA esters were not directly correlated with the percentage contributions of the corresponding fatty acids to the triacylglycerol stores. Despite very pronounced differences in the biochemistry, physiology, and physical activity of each life-cycle stage, as well as in the fatty acid composition of the triacylglycerols, before and after the adult trophic phase, the V(max) for CPT I was always greatest for 16:1n-7 and 18:1n-9. Because the reactivity of CPT I towards the latter two monoenoic fatty acids is also high in teleost fishes and in rat, such a characteristic may have been conserved throughout vertebrate evolution.

Details

UN Sustainable Development Goals (SDGs)

This output has contributed to the advancement of the following goals:

#3 Good Health and Well-Being

Source: InCites

Metrics

44 Record Views
6 Times Cited - Web of Science

InCites Highlights

These are selected metrics from InCites Benchmarking & Analytics tool, related to this output

Citation topics
1 Clinical & Life Sciences
1.197 Molecular & Cell Biology - Mitochondria
1.197.1196 Inborn Metabolic Errors
Web Of Science research areas
Zoology
ESI research areas
Plant & Animal Science
Logo image