Journal article
Kinetics of Photo-Oxidation of oxazole and its substituents by singlet oxygen
Scientific Reports, Vol.10(1), Art. 3668
2020
Abstract
Oxazole has critical roles not only in heterocycle (bio)chemistry research, but also as the backbone of many active natural and medicinal species. These diverse and specialised functions can be attributed to the unique physicochemical properties of oxazole. This contribution investigates the reaction of oxazole and its derivatives with singlet oxygen, employing density functional theory DFT-B3LYP calculations. The absence of allylic hydrogen in oxazole eliminates the ene-mode addition of singlet oxygen to the aromatic ring. Therefore, the primary reaction pathway constitutes the [4 + 2]-cycloaddition of singlet oxygen to oxazole ring, favouring an energetically accessible corridor of 57 kJ/mol to produce imino-anhydride which is postulated to convert to triamide end-product in subsequent steps. The pseudo-first-order reaction rate for substituted oxazole (e.g., 4-methyl-2,5-diphenyloxazole, 1.14 × 106 M−1 s−1) appears slightly higher than that of unsubstituted oxazole (0.94 × 106 M−1 s−1) considering the same initial concentration of the species at 300 K, due to the electronic effect of the functional groups. The global reactivity descriptors have justified the relative influence of the functional groups along with their respective physiochemical properties.
Details
- Title
- Kinetics of Photo-Oxidation of oxazole and its substituents by singlet oxygen
- Authors/Creators
- N. Zeinali (Author/Creator) - Murdoch UniversityI. Oluwoye (Author/Creator) - Murdoch UniversityM. Altarawneh (Author/Creator) - United Arab Emirates UniversityB.Z. Dlugogorski (Author/Creator) - Charles Darwin University
- Publication Details
- Scientific Reports, Vol.10(1), Art. 3668
- Publisher
- Springer Nature
- Identifiers
- 991005541509407891
- Copyright
- © 2020 The Author(s)
- Murdoch Affiliation
- Chemistry and Physics
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
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- Citation topics
- 2 Chemistry
- 2.1 Synthesis
- 2.1.40 Total Synthesis
- Web Of Science research areas
- Chemistry, Multidisciplinary
- ESI research areas
- Chemistry