Klotho allele status is not associated with Aβ and APOE ε4–related cognitive decline in preclinical Alzheimer's disease

T. Porter; S.C. Burnham; L. Milicic; G. Savage; P. Maruff; Y.Y. Lim; D. Ames; C.L. Masters; R.N. Martins; S. Rainey-Smith; C.C. Rowe; O. Salvado; D. Groth; G. Verdile; V.L. Villemagne; S.M. Laws

doi:10.1016/j.neurobiolaging.2018.12.014

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Klotho allele status is not associated with Aβ and APOE ε4–related cognitive decline in preclinical Alzheimer's disease

Journal article

Peer reviewed

Klotho allele status is not associated with Aβ and APOE ε4–related cognitive decline in preclinical Alzheimer's disease

T. Porter, S.C. Burnham, L. Milicic, G. Savage, P. Maruff, Y.Y. Lim, D. Ames, C.L. Masters, R.N. Martins, S. Rainey-Smith, …

Neurobiology of Aging, Vol.76, pp.162-165

2019

DOI: https://doi.org/10.1016/j.neurobiolaging.2018.12.014

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Abstract

The longevity gene Klotho (KL), specifically the functional KL-VS variant, has previously been associated with cognition and rates of cognitive decline. This study aimed to determine whether KL-VS associations with cognition were observable in preclinical Alzheimer's disease (AD). The study also aimed to determine whether there was a combined influence of KL-VS, neocortical amyloid-β (Aβ) burden, and carriage of the apolipoprotein E (APOE) ε4 allele on cognitive decline. This study involved 581 Aβ-imaged, cognitively normal older adults, enrolled in the Australian Imaging, Biomarkers and Lifestyle Study of Aging. Linear mixed effects models revealed no significant associations between KL-VS and cognitive decline independently or in combination with Aβ burden and APOE ε4 genotype. Overall, previous associations reported between KL-VS and cognitive decline are not observed at the preclinical stages of AD. Furthermore, the results do not support the hypothesis that KL-VS has a modifying effect on Aβ burden and APOE ε4–driven cognitive decline in preclinical AD.

Details

Title: Klotho allele status is not associated with Aβ and APOE ε4–related cognitive decline in preclinical Alzheimer's disease
Authors/Creators: T. Porter (Author/Creator)
S.C. Burnham (Author/Creator) - Edith Cowan University
L. Milicic (Author/Creator) - Edith Cowan University
G. Savage (Author/Creator) - Macquarie University
P. Maruff (Author/Creator) - Florey Institute of Neuroscience and Mental Health
Y.Y. Lim (Author/Creator) - Florey Institute of Neuroscience and Mental Health
D. Ames (Author/Creator) - National Ageing Research Institute
C.L. Masters (Author/Creator) - Florey Institute of Neuroscience and Mental Health
R.N. Martins (Author/Creator) - Edith Cowan University
S. Rainey-Smith (Author/Creator) - Centre for Mental Health
C.C. Rowe (Author/Creator) - Austin Health
O. Salvado (Author/Creator) - Australian e-Health Research Centre
D. Groth (Author/Creator) - Curtin University
G. Verdile (Author/Creator) - Edith Cowan University
V.L. Villemagne (Author/Creator) - Florey Institute of Neuroscience and Mental Health
S.M. Laws (Author/Creator) - Cooperative Research Centre for Mental Health
Publication Details: Neurobiology of Aging, Vol.76, pp.162-165
Publisher: Elsevier Inc
Identifiers: 991005540390507891
Copyright: © 2019 Elsevier Inc.
Murdoch Affiliation: Murdoch University
Language: English
Resource Type: Journal article

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Collaboration types: Industry collaboration; Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.80 Bone Diseases; 1.80.348 Parathyroid Disorders
Web Of Science research areas: Geriatrics & Gerontology; Neurosciences
ESI research areas: Neuroscience & Behavior