Laboratory-based surveillance of Clostridium difficile Infection in Australian health care and community settings, 2013 to 2018

S. Hong; P. Putsathit; N. George; C. Hemphill; P.G. Huntington; T.M. Korman; D. Kotsanas; M. Lahra; R. McDougall; C.V. Moore; G.R. Nimmo; L. Prendergast; J. Robson; L. Waring; M.C. Wehrhahn; G.F. Weldhagen; R.M. Wilson; T.V. Riley; D.R. Knight; D.J. Diekema

doi:10.1128/JCM.01552-20

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Laboratory-based surveillance of Clostridium difficile Infection in Australian health care and community settings, 2013 to 2018

Journal article

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Laboratory-based surveillance of Clostridium difficile Infection in Australian health care and community settings, 2013 to 2018

S. Hong, P. Putsathit, N. George, C. Hemphill, P.G. Huntington, T.M. Korman, D. Kotsanas, M. Lahra, R. McDougall, C.V. Moore, …

Journal of Clinical Microbiology, Vol.58(11), pp.e01552-20

2020

DOI: https://doi.org/10.1128/JCM.01552-20

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Abstract

In the early 2000s, a binary toxin (CDT)-producing strain of Clostridium difficile, ribotype 027 (RT027), caused extensive outbreaks of diarrheal disease in North America and Europe. This strain has not become established in Australia, and there is a markedly different repertoire of circulating strains there compared to other regions of the world. The C. difficile Antimicrobial Resistance Surveillance (CDARS) study is a nationwide longitudinal surveillance study of C. difficile infection (CDI) in Australia. Here, we describe the molecular epidemiology of CDI in Australian health care and community settings over the first 5 years of the study, 2013 to 2018. Between 2013 and 2018, 10 diagnostic microbiology laboratories from five states in Australia participated in the CDARS study. From each of five states, one private (representing community) and one public (representing hospitals) laboratory submitted isolates of C. difficile or PCR-positive stool samples during two collection periods per year, February-March (summer/autumn) and August-September (winter/spring). C. difficile was characterized by toxin gene profiling and ribotyping. A total of 1,523 isolates of C. difficile were studied. PCR ribotyping yielded 203 different RTs, the most prevalent being RT014/020 (n = 449; 29.5%). The epidemic CDT+ RT027 (n = 2) and RT078 (n = 6), and the recently described RT251 (n = 10) and RT244 (n = 6) were not common, while RT126 (n = 17) was the most prevalent CDT+ type. A heterogeneous C. difficile population was identified. C. difficile RT014/020 was the most prevalent type found in humans with CDI. Continued surveillance of CDI in Australia remains critical for the detection of emerging strain lineages.

Details

Title: Laboratory-based surveillance of Clostridium difficile Infection in Australian health care and community settings, 2013 to 2018
Authors/Creators: S. Hong (Author/Creator) - Murdoch University
P. Putsathit (Author/Creator) - Edith Cowan University
N. George (Author/Creator) - Royal Brisbane and Women's Hospital
C. Hemphill (Author/Creator) - Melbourne Pathology, Collingwood, VIC, Australia
P.G. Huntington (Author/Creator) - Royal North Shore Hospital
T.M. Korman (Author/Creator) - Monash Medical Centre
D. Kotsanas (Author/Creator) - Monash Medical Centre
M. Lahra (Author/Creator) - Prince of Wales Hospital
R. McDougall (Author/Creator) - Sullivan Nicolaides Pathology
C.V. Moore (Author/Creator) - South Australia Pathology
G.R. Nimmo (Author/Creator) - Royal Brisbane and Women's Hospital
L. Prendergast (Author/Creator) - Melbourne Pathology, Collingwood, VIC, Australia
J. Robson (Author/Creator) - Sullivan Nicolaides Pathology
L. Waring (Author/Creator) - Melbourne Pathology, Collingwood, VIC, Australia
M.C. Wehrhahn (Author/Creator) - Douglass Hanly Moir Pathology
G.F. Weldhagen (Author/Creator) - South Australia Pathology
R.M. Wilson (Author/Creator) - Australian Clinical Labs, Microbiology Department, Wayville, SA, Australia.
T.V. Riley (Author/Creator) - Queen Elizabeth II Medical Centre
D.R. Knight (Author/Creator) - Murdoch University
D.J. Diekema (Author/Creator)
Publication Details: Journal of Clinical Microbiology, Vol.58(11), pp.e01552-20
Publisher: American Society for Microbiology
Identifiers: 991005541685607891
Copyright: © 2020 American Society for Microbiology
Murdoch Affiliation: School of Medical, Molecular and Forensic Sciences
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.120 Inflammatory Bowel Diseases & Infections; 1.120.1133 Clostridium Infections
Web Of Science research areas: Microbiology
ESI research areas: Microbiology