Journal article
Large burden of stroke incidence in people with cardiac disease: a linked data cohort study
Clinical epidemiology, Vol.15, pp.203-211
2023
PMID: 36846512
Abstract
Purpose
People with cardiac disease have 2– 4 times greater risk of stroke than the general population. We measured stroke incidence in people with coronary heart disease (CHD), atrial fibrillation (AF) or valvular heart disease (VHD).
Methods
We used a person-linked hospitalization/mortality dataset to identify all people hospitalized with CHD, AF or VHD (1985– 2017), and stratified them as pre-existing (hospitalized 1985– 2012 and alive at October 31, 2012) or new (first-ever cardiac hospitalization in the five-year study period, 2012– 2017). We identified first-ever strokes occurring from 2012 to 2017 in patients aged 20– 94 years and calculated age-specific and age-standardized rates (ASR) for each cardiac cohort.
Results
Of the 175,560 people in the cohort, most had CHD (69.9%); 16.3% had multiple cardiac conditions. From 2012– 17, 5871 first-ever strokes occurred. ASRs were greater in females than males in single and multiple condition cardiac groups, largely driven by rates in females aged ≥ 75 years, with stroke incidence in this age group being at least 20% greater in females than males in each cardiac subgroup. In females aged 20– 54 years, stroke incidence was 4.9-fold greater in those with multiple versus single cardiac conditions. This differential declined with increasing age. Non-fatal stroke incidence was greater than fatal stroke in all age groups except in the 85– 94 age group. Incidence rate ratios were up to 2-fold larger in new versus pre-existing cardiac disease.
Conclusion
Stroke incidence in people with cardiac disease is substantial, with older females, and younger patients with multiple cardiac conditions, at elevated risk. These patients should be specifically targeted for evidence-based management to minimize the burden of stroke.
Details
- Title
- Large burden of stroke incidence in people with cardiac disease: a linked data cohort study
- Authors/Creators
- Keira Robinson - The University of Western AustraliaJudith M. Katzenellenbogen - The University of Western AustraliaTimothy J. Kleinig - Royal Adelaide HospitalJoosup Kim - Monash HealthCharley A. Budgeon - The University of Western AustraliaAmanda G. Thrift - Monash HealthLee Nedkoff - The University of Western Australia
- Publication Details
- Clinical epidemiology, Vol.15, pp.203-211
- Publisher
- Dove Medical Press Ltd
- Number of pages
- 9
- Grant note
- 1182071 / National Health and Medical Research Council of Australia Synergy grant; National Health & Medical Research Council (NHMRC) of Australia
- Identifiers
- 991005884935407891
- Copyright
- © 2023 Robinson et al.
- Murdoch Affiliation
- Ngangk Yira Institute for Change
- Language
- English
- Resource Type
- Journal article
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