Learning deficit in cognitively normal APOE ε4 carriers with LOW β‐amyloid

Y.Y. Lim; J.E. Baker; A. Mills; L. Bruns; C. Fowler; J. Fripp; S.R. Rainey‐Smith; D. Ames; C.L. Masters; P. Maruff

doi:10.1002/dad2.12136

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Learning deficit in cognitively normal APOE ε4 carriers with LOW β‐amyloid

Journal article

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Learning deficit in cognitively normal APOE ε4 carriers with LOW β‐amyloid

Y.Y. Lim, J.E. Baker, A. Mills, L. Bruns, C. Fowler, J. Fripp, S.R. Rainey‐Smith, D. Ames, C.L. Masters and P. Maruff

Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol.13(1), Art. e12136

2021

DOI: https://doi.org/10.1002/dad2.12136

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Abstract

Introduction In cognitively normal (CN) adults, increased rates of amyloid beta (Aβ) accumulation can be detected in low Aβ (Aβ–) apolipoprotein E (APOE) ε4 carriers. We aimed to determine the effect of ε4 on the ability to benefit from experience (ie, learn) in Aβ– CNs. Methods Aβ– CNs (n = 333) underwent episodic memory assessments every 18 months for 108 months. A subset (n = 48) completed the Online Repeatable Cognitive Assessment‐Language Learning Test (ORCA‐LLT) over 6 days. Results Aβ– ε4 carriers showed significantly lower rates of improvement on episodic memory over 108 months compared to non‐carriers (d = 0.3). Rates of learning on the ORCA‐LLT were significantly slower in Aβ– ε4 carriers compared to non‐carriers (d = 1.2). Discussion In Aβ– CNs, ε4 is associated with a reduced ability to benefit from experience. This manifested as reduced practice effects (small to moderate in magnitude) over 108 months on the episodic memory composite, and a learning deficit (large in magnitude) over 6 days on the ORCA‐LLT. Alzheimer's disease (AD)–related cognitive abnormalities can manifest before preclinical AD thresholds.

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Title: Learning deficit in cognitively normal APOE ε4 carriers with LOW β‐amyloid
Authors/Creators: Y.Y. Lim (Author/Creator) - Florey Institute of Neuroscience and Mental Health
J.E. Baker (Author/Creator) - Florey Institute of Neuroscience and Mental Health
A. Mills (Author/Creator) - Monash University
L. Bruns (Author/Creator) - The University of Melbourne
C. Fowler (Author/Creator) - Florey Institute of Neuroscience and Mental Health
J. Fripp (Author/Creator) - Australian e-Health Research Centre
S.R. Rainey‐Smith (Author/Creator)
D. Ames (Author/Creator) - The University of Melbourne
C.L. Masters (Author/Creator) - Florey Institute of Neuroscience and Mental Health
P. Maruff (Author/Creator) - Florey Institute of Neuroscience and Mental Health
Publication Details: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol.13(1), Art. e12136
Publisher: Elsevier Inc. on behalf of the Alzheimer’s Association
Identifiers: 991005542356007891
Murdoch Affiliation: Murdoch University
Language: English
Resource Type: Journal article

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