Length variation of CAG/CAA triplet repeats in 50 genes among 16 inbred mouse strains

M. Ogasawara; T. Imanishi; K. Moriwaki; S. Gaudieri; H. Tsuda; H. Hashimoto; T. Shiroishi; T. Gojobori; T. Koide

doi:10.1016/j.gene.2004.11.050

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Length variation of CAG/CAA triplet repeats in 50 genes among 16 inbred mouse strains

Journal article

Peer reviewed

Length variation of CAG/CAA triplet repeats in 50 genes among 16 inbred mouse strains

M. Ogasawara, T. Imanishi, K. Moriwaki, S. Gaudieri, H. Tsuda, H. Hashimoto, T. Shiroishi, T. Gojobori and T. Koide

Gene, Vol.349, pp.107-119

2005

DOI: https://doi.org/10.1016/j.gene.2004.11.050

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Abstract

CAG repeats coding for poly-glutamines have been studied by many groups as repeat length variations contributes to differences in protein function and disease outcome. In this study, we systematically searched public databases for genes carrying CAG repeats. For the genes obtained, we experimentally analyzed variations of length and the purity of the repeats in 62 loci among 16 inbred mouse strains, including wild-derived and laboratory strains. We found that length was conserved in 50% of the loci, especially among wild-derived strains. Of 496 polymorphic repeat alleles, 78% were uninterrupted and 22% were interrupted with non-CAG codons. Interruptions tended to occur in longer repeats and all repeats of greater length than 23 were interrupted. Although interruptions can act as suppressors for the expansion of CAG repeats, we found that the occurrence of the interruptions depended on the length of the CAG repeats. Furthermore, most poly-glutamines examined in this study existed in human orthologous genes, reflecting the functional significance of poly-glutamines in proteins.

Details

Title: Length variation of CAG/CAA triplet repeats in 50 genes among 16 inbred mouse strains
Authors/Creators: M. Ogasawara (Author/Creator) - National Institute of Genetics
T. Imanishi (Author/Creator) - National Institute of Advanced Industrial Science and Technology
K. Moriwaki (Author/Creator) - RIKEN BioResource Research Center
S. Gaudieri (Author/Creator) - The University of Western Australia
H. Tsuda (Author/Creator) - Juntendo University
H. Hashimoto (Author/Creator) - Juntendo University
T. Shiroishi (Author/Creator) - National Institute of Genetics
T. Gojobori (Author/Creator) - National Institute of Genetics
T. Koide (Author/Creator) - The Graduate University for Advanced Studies, SOKENDAI
Publication Details: Gene, Vol.349, pp.107-119
Publisher: Elsevier BV
Identifiers: 991005544528007891
Copyright: © Elsevier B.V.
Murdoch Affiliation: Institute for Immunology and Infectious Diseases
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.52 Neurodegenerative Diseases; 1.52.951 Huntington's and Ataxias
Web Of Science research areas: Genetics & Heredity
ESI research areas: Molecular Biology & Genetics