Journal article
Leukocyte Ig-like receptor complex (LRC) in mice and me
Trends in Immunology, Vol.23(2), pp.81-88
2002
Abstract
Here, we compare the architecture of membrane receptors with extracellular Ig-like domains located within the leukocyte Ig-like receptor complex (LRC) of humans and mice. The receptors can be classified broadly into four groups, based on the homology of their Ig-like domains and gene architecture. Receptors in the first group are characterized by the presence of the Ig constant type 2-1 (IgC2-1) and variant Ig (vIg) domains, and include the leukocyte Ig-like receptors (LILRs) and murine paired Ig-activating receptors (PIRs). The second group of receptors possess an IgC2-2 domain and comprise the killer-cell Ig-like receptors (KIRs) and platelet collagen receptor glycoprotein VI (GPVI). The third group consists of receptors with IgC2-1, and IgC2-3 or IgC2-4 domains, and includes the receptor for IgA Fc (FCAR), NKp46 and murine Ly94. The fourth group, with a single extracellular IgC2-1 domain, consists of the leukocyte-associated Ig-like receptors (LAIRs). The genomic organization of and evolutionary associations between these receptors and their domains are examined.
Details
- Title
- Leukocyte Ig-like receptor complex (LRC) in mice and me
- Authors/Creators
- A.M. Martin (Author/Creator)J.K. Kulski (Author/Creator)C. Witt (Author/Creator)P. Pontarotti (Author/Creator)F.T. Christiansen (Author/Creator)
- Publication Details
- Trends in Immunology, Vol.23(2), pp.81-88
- Publisher
- Elsevier
- Identifiers
- 991005543042807891
- Copyright
- © 2002 Elsevier Science Ltd.
- Murdoch Affiliation
- School of Information Technology
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.6 Immunology
- 1.6.1021 Natural Killer Cells
- Web Of Science research areas
- Immunology
- ESI research areas
- Immunology