Journal article
Levels of innate immune factors in preterm and term mothers’ breast milk during the 1st month postpartum
British Journal of Nutrition, Vol.115(7), pp.1178-1193
2016
Abstract
There is a paucity of data on the effect of preterm birth on the immunological composition of breast milk throughout the different stages of lactation. We aimed to characterise the effects of preterm birth on the levels of immune factors in milk during the 1st month postpartum, to determine whether preterm milk is deficient in antimicrobial factors. Colostrum (days 2–5 postpartum), transitional milk (days 8–12) and mature milk (days 26–30) were collected from mothers of extremely preterm (<28 weeks of gestation, n 15), very preterm (28–<32 weeks of gestation, n 15), moderately preterm (32–<37 weeks of gestation, n 15) and term infants (37–41 weeks of gestation, n 15). Total protein, lactoferrin, secretory IgA, soluble CD14 receptor (sCD14), transforming growth factor-β2 (TGF-β2), α defensin 5 (HD5), β defensins 1 (HBD1) and 2, IL-6, IL-10, IL-13, interferon-γ, TNF-α and lysozyme (LZ) were quantified in milk. We examined the effects of lactation stage, gestational age, volume of milk expressed, mode of delivery, parity and maternal infection on milk immune factor concentrations using repeated-measures regression analysis. The concentrations of all factors except LZ and HD5 decreased over the 1st month postpartum. Extremely preterm mothers had significantly higher concentrations of HBD1 and TGF-β2 in colostrum than term mothers did. After controlling for other variables in regression analyses, preterm birth was associated with higher concentrations of HBD1, LZ and sCD14 in milk samples. In conclusion, preterm breast milk contains significantly higher concentrations of some immune proteins than term breast milk.
Details
- Title
- Levels of innate immune factors in preterm and term mothers’ breast milk during the 1st month postpartum
- Authors/Creators
- S. Trend (Author/Creator) - The University of Western AustraliaT. Strunk (Author/Creator) - The University of Western AustraliaM.L. Lloyd (Author/Creator) - The University of Western AustraliaC.H. Kok (Author/Creator) - The University of Western AustraliaJ. Metcalfe (Author/Creator) - The University of Western AustraliaD.T. Geddes (Author/Creator) - The University of Western AustraliaC.T. Lai (Author/Creator) - The University of Western AustraliaP. Richmond (Author/Creator) - The University of Western AustraliaD.A. Doherty (Author/Creator) - The University of Western AustraliaK. Simmer (Author/Creator) - The University of Western AustraliaA. Currie (Author/Creator) - The University of Western Australia
- Publication Details
- British Journal of Nutrition, Vol.115(7), pp.1178-1193
- Publisher
- Cambridge University Press
- Identifiers
- 991005541223907891
- Copyright
- © The Authors 2016
- Murdoch Affiliation
- School of Veterinary and Life Sciences
- Language
- English
- Resource Type
- Journal article
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
Source: InCites
Metrics
32 Record Views
InCites Highlights
These are selected metrics from InCites Benchmarking & Analytics tool, related to this output
- Collaboration types
- Domestic collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.72 Obstetrics & Gynecology
- 1.72.891 Breastfeeding
- Web Of Science research areas
- Nutrition & Dietetics
- ESI research areas
- Agricultural Sciences