Life cycle heterogeneity in animal models of human papillomavirus-associated disease

W.L. Peh; W.J. Liu; J. Doorbar; K. Middleton; N. Christensen; P.K. Nicholls; K. Egawa; K. Sotlar; J. Brandsma; A. Percival; J. Lewis

doi:10.1128/JVI.76.20.10401-10416.2002

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Life cycle heterogeneity in animal models of human papillomavirus-associated disease

Journal article

Open access

Peer reviewed

Life cycle heterogeneity in animal models of human papillomavirus-associated disease

W.L. Peh, W.J. Liu, J. Doorbar, K. Middleton, N. Christensen, P.K. Nicholls, K. Egawa, K. Sotlar, J. Brandsma, A. Percival, …

Journal of Virology, Vol.76(20), pp.10401-10416

2002

DOI: https://doi.org/10.1128/JVI.76.20.10401-10416.2002

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Abstract

Animal papillomaviruses are widely used as models to study papillomavirus infection in humans despite differences in genome organization and tissue tropism. Here, we have investigated the extent to which animal models of papillomavirus infection resemble human disease by comparing the life cycles of 10 different papillomavirus types. Three phases in the life cycles of all viruses were apparent using antibodies that distinguish between early events, the onset of viral genome amplification, and the expression of capsid proteins. The initiation of these phases follows a highly ordered pattern that appears important for the production of virus particles. The viruses examined included canine oral papillomavirus, rabbit oral papillomavirus (ROPV), cottontail rabbit papillomavirus (CRPV), bovine papillomavirus type 1, and human papillomavirus types 1, 2, 11, and 16. Each papillomavirus type showed a distinctive gene expression pattern that could be explained in part by differences in tissue tropism, transmission route, and persistence. As the timing of life cycle events affects the accessibility of viral antigens to the immune system, the ideal model system should resemble human mucosal infection if vaccine design is to be effective. Of the model systems examined here, only ROPV had a tissue tropism and a life cycle organization that resembled those of the human mucosal types. ROPV appears most appropriate for studies of the life cycles of mucosal papillomavirus types and for the development of prophylactic vaccines. The persistence of abortive infections caused by CRPV offers advantages for the development of therapeutic vaccines.

Details

Title: Life cycle heterogeneity in animal models of human papillomavirus-associated disease
Authors/Creators: W.L. Peh (Author/Creator)
W.J. Liu (Author/Creator)
J. Doorbar (Author/Creator)
K. Middleton (Author/Creator)
N. Christensen (Author/Creator)
P.K. Nicholls (Author/Creator)
K. Egawa (Author/Creator)
K. Sotlar (Author/Creator)
J. Brandsma (Author/Creator)
A. Percival (Author/Creator)
J. Lewis (Author/Creator)
Publication Details: Journal of Virology, Vol.76(20), pp.10401-10416
Publisher: American Society for Microbiology
Identifiers: 991005541003607891
Copyright: Copyright (c) 2002, American Society for Microbiology. All Rights Reserved.
Murdoch Affiliation: School of Veterinary and Biomedical Sciences
Language: English
Resource Type: Journal article

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Collaboration types: Industry collaboration; Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.179 Oncology; 1.179.108 HPV and Cervical Cancer
Web Of Science research areas: Virology
ESI research areas: Microbiology