Limited evidence for alterations in Gag-mediated HIV replication capacity over the course of the North American epidemic (1979-present)

L. Cotton; D. Chopera; K. Penney; J. Carlson; E. Martin; A. Le; T. Kuang; B. Walker; J. Fuchs; S. Buchbinder; T. Wagner; M. John; S. Mallal; B. Koblin; K. Mayer; A. Poon; M. Brockman; Z. Brumme

doi:10.1186/1742-4690-9-S2-P157

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Limited evidence for alterations in Gag-mediated HIV replication capacity over the course of the North American epidemic (1979-present)

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Limited evidence for alterations in Gag-mediated HIV replication capacity over the course of the North American epidemic (1979-present)

L. Cotton, D. Chopera, K. Penney, J. Carlson, E. Martin, A. Le, T. Kuang, B. Walker, J. Fuchs, S. Buchbinder, …

Retrovirology, Vol.9(Suppl 2), P157

2012

DOI: https://doi.org/10.1186/1742-4690-9-S2-P157

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Abstract

The extent to which HIV replication capacity (RC) has changed over the epidemic’s course, and the influence of HLA-associated immune pressure as its driving force remains unknown. We performed a comparative study of immune escape and RC in historic (1979-1989) and modern Gag subtype B sequences from North America.

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Title: Limited evidence for alterations in Gag-mediated HIV replication capacity over the course of the North American epidemic (1979-present)
Authors/Creators: L. Cotton (Author/Creator) - Simon Fraser University
D. Chopera (Author/Creator) - Simon Fraser University
K. Penney (Author/Creator) - Simon Fraser University
J. Carlson (Author/Creator) - Microsoft (United States)
E. Martin (Author/Creator) - Simon Fraser University
A. Le (Author/Creator) - Simon Fraser University
T. Kuang (Author/Creator) - Simon Fraser University
B. Walker (Author/Creator) - Ragon Institute of MGH, MIT and Harvard
J. Fuchs (Author/Creator) - San Francisco Department of Public Health
S. Buchbinder (Author/Creator) - San Francisco Department of Public Health
T. Wagner (Author/Creator) - San Francisco Department of Public Health
M. John (Author/Creator) - Murdoch University
S. Mallal (Author/Creator) - Murdoch University
B. Koblin (Author/Creator) - New York Blood Center
K. Mayer (Author/Creator) - Fenway Health
A. Poon (Author/Creator)
M. Brockman (Author/Creator) - Simon Fraser University
Z. Brumme (Author/Creator) - Simon Fraser University
Publication Details: Retrovirology, Vol.9(Suppl 2), P157
Publisher: BioMed Central
Identifiers: 991005542451907891
Murdoch Affiliation: Institute for Immunology and Infectious Diseases
Language: English
Resource Type: Journal article
Note: Poster Presentation at AIDS Vaccine 2012, Boston, 9-12 September, 2012.

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Collaboration types: Industry collaboration; Domestic collaboration; International collaboration
Citation topics: No Topic Assigned; No Topic Assigned; No Topic Assigned
Web Of Science research areas: Virology
ESI research areas: Microbiology