Live high, train low - influence on resting and post-exercise hepcidin levels

A.D. Govus; P. Peeling; C.R. Abbiss; N.G. Lawler; D.W. Swinkels; C.M. Laarakkers; K.G. Thompson; J.J. Peiffer; C.J. Gore; L.A. Garvican-Lewis

doi:10.1111/sms.12685

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Live high, train low - influence on resting and post-exercise hepcidin levels

Journal article

Peer reviewed

Live high, train low - influence on resting and post-exercise hepcidin levels

A.D. Govus, P. Peeling, C.R. Abbiss, N.G. Lawler, D.W. Swinkels, C.M. Laarakkers, K.G. Thompson, J.J. Peiffer, C.J. Gore and L.A. Garvican-Lewis

Scandinavian Journal of Medicine & Science in Sports, Vol.27(7), pp.704-713

2017

DOI: https://doi.org/10.1111/sms.12685

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Abstract

The post-exercise hepcidin response during prolonged (>2 weeks) hypoxic exposure is not well understood. We compared plasma hepcidin levels 3 h after exercise [6 × 1000 m at 90% of maximal aerobic running velocity (vVO2max)] performed in normoxia and normobaric hypoxia (3000 m simulate altitude) 1 week before, and during 14 days of normobaric hypoxia [196.2 ± 25.6 h (median: 200.8 h; range: 154.3–234.8 h) at 3000 m simulated altitude] in 10 well-trained distance runners (six males, four females). Venous blood was also analyzed for hepcidin after 2 days of normobaric hypoxia. Hemoglobin mass (Hbmass) was measured via CO rebreathing 1 week before and after 14 days of hypoxia. Hepcidin was suppressed after 2 (Cohen's d = −2.3, 95% confidence interval: [−2.9, −1.6]) and 14 days of normobaric hypoxia (d = −1.6 [−2.6, −0.6]). Hepcidin increased from baseline, 3 h post-exercise in normoxia (d = 0.8 [0.2, 1.3]) and hypoxia (d = 0.6 [0.3, 1.0]), both before and after exposure (normoxia: d = 0.7 [0.3, 1.2]; hypoxia: d = 1.3 [0.4, 2.3]). In conclusion, 2 weeks of normobaric hypoxia suppressed resting hepcidin levels, but did not alter the post-exercise response in either normoxia or hypoxia, compared with the pre-exposure response.

Details

Title: Live high, train low - influence on resting and post-exercise hepcidin levels
Authors/Creators: A.D. Govus (Author/Creator) - University of Bedfordshire
P. Peeling (Author/Creator) - The University of Western Australia
C.R. Abbiss (Author/Creator) - Edith Cowan University
N.G. Lawler (Author/Creator) - Murdoch University
D.W. Swinkels (Author/Creator) - Radboud University Medical Center
C.M. Laarakkers (Author/Creator) - Radboud University Medical Center
K.G. Thompson (Author/Creator) - Australian Institute of Sport
J.J. Peiffer (Author/Creator) - Murdoch University
C.J. Gore (Author/Creator) - Flinders University
L.A. Garvican-Lewis (Author/Creator) - Australian Institute of Sport
Publication Details: Scandinavian Journal of Medicine & Science in Sports, Vol.27(7), pp.704-713
Publisher: Wiley
Identifiers: 991005540426807891
Copyright: © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
Murdoch Affiliation: School of Psychology and Exercise Science
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.184 Physiology & Metals; 1.184.573 Iron Metabolism
Web Of Science research areas: Sport Sciences
ESI research areas: Clinical Medicine