Journal article
Liver inflammation and cytokine production, but not acute phase protein synthesis, accompany the adult liver progenitor (oval) cell response to chronic liver injury
Immunology and Cell Biology, Vol.83(4), pp.364-374
2005
Abstract
Oval cells are facultative liver progenitor cells, which are invoked during chronic liver injury in order to replenish damaged hepatocytes and bile duct cells. Previous studies have observed inflammation and cytokine production in the liver during chronic injury. Further, it has been proposed that inflammatory growth factors may mediate the proliferation of oval cells during disease progression. We have undertaken a detailed examination of inflammation and cytokine production during a time course of liver injury and repair, invoked by feeding mice a choline-deficient, ethionine-supplemented (CDE) diet. We show that immediately following initial liver injury, B220-expressing leucocytes transiently infiltrate the liver. This inflammatory response occurred immediately before oval cell numbers began to expand in the liver, suggesting that the two events may be linked. Two waves of liver cytokine production were observed during the CDE time course. The first occurred shortly following commencement of the diet, suggesting that it may represent a hepatic acute phase response. However, examination of acute phase marker expression in CDE-fed mice did not support this hypothesis. The second wave of cytokine expression correlated with the expansion of oval cell numbers in the liver, suggesting that these factors may mediate oval cell proliferation. No inflammatory signalling was detected following withdrawal of the injury stimulus. In summary, our results document a close correlation between inflammation, cytokine production and the expansion of oval cells in the liver during experimental chronic injury.
Details
- Title
- Liver inflammation and cytokine production, but not acute phase protein synthesis, accompany the adult liver progenitor (oval) cell response to chronic liver injury
- Authors/Creators
- B. Knight (Author/Creator) - The University of Western AustraliaV.B. Matthews (Author/Creator)B. Akhurst (Author/Creator) - The University of Western AustraliaE.J. Croager (Author/Creator) - The University of Western AustraliaE. Klinken (Author/Creator) - The University of Western AustraliaL.J. Abraham (Author/Creator) - The University of Western AustraliaJ.K. Olynyk (Author/Creator) - The University of Western AustraliaG. Yeoh (Author/Creator)
- Publication Details
- Immunology and Cell Biology, Vol.83(4), pp.364-374
- Publisher
- Nature Publishing Group
- Identifiers
- 991005541565307891
- Copyright
- © 2005 Australasian Society for Immunology Inc.
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.102 Stem Cell Research
- 1.102.1150 Hepatocyte Growth Factor
- Web Of Science research areas
- Cell Biology
- Immunology
- ESI research areas
- Immunology