Journal article
Locked nucleic acid as a novel class of therapeutic agents
RNA Biology, Vol.6(3), pp.321-323
2009
Abstract
Locked Nucleic Acid (LNA) is a nucleic acid analogue with unprecedented binding affinity and excellent specificity toward complementary RNA and DNA oligonucleotides. The remarkable properties of LNA have led to applications within various gene silencing strategies both in vitro and in vivo. In the present review, we highlight the uses of LNA for regulation of gene expression with emphasis on RNA targeting.
Details
- Title
- Locked nucleic acid as a novel class of therapeutic agents
- Authors/Creators
- R.N. Veedu (Author/Creator) - University of Southern DenmarkJ. Wengel (Author/Creator)
- Publication Details
- RNA Biology, Vol.6(3), pp.321-323
- Publisher
- Taylor & Francis
- Identifiers
- 991005542913407891
- Copyright
- © 2009 Landes Bioscience
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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Source: InCites
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- Citation topics
- 2 Chemistry
- 2.170 Nucleic Acids Chemistry
- 2.170.988 Oligonucleotide Modifications
- Web Of Science research areas
- Biochemistry & Molecular Biology
- ESI research areas
- Biology & Biochemistry