Journal article
Locked nucleic acid nucleoside triphosphates and polymerases: On the way towards evolution of LNA aptamers
Molecular BioSystems, Vol.5(8)
2009
Abstract
Among numerous nucleic acid analogs reported in the past decades, locked nucleic acid (LNA) has received substantial attention and has become a significant tool within chemical biology disciplines like molecular biology research, diagnostics and therapeutic development. However, despite their obvious structurally unique properties, LNA-based aptamers for diagnostic and therapeutic applications remain largely unexplored. Future evolution of LNAoligonucleotideaptamers will depend on scientific breakthroughs relating to enzymatic polymerization using LNAnucleoside triphosphates as substrates. Herein, we highlight recent developments in this direction using various polymerases.
Details
- Title
- Locked nucleic acid nucleoside triphosphates and polymerases: On the way towards evolution of LNA aptamers
- Authors/Creators
- R.N. Veedu (Author/Creator) - University of Southern DenmarkJ. Wengel (Author/Creator) - University of Southern Denmark
- Publication Details
- Molecular BioSystems, Vol.5(8)
- Publisher
- Royal Society of Chemistry
- Identifiers
- 991005542806307891
- Copyright
- © 2009 Royal Society of Chemistry
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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