Journal article
Locked nucleic acids: Promising nucleic acid analogs for therapeutic applications
Chemistry & Biodiversity, Vol.7(3), pp.536-542
2010
Abstract
Locked Nucleic Acid (LNA) is a unique nucleic-acid modification possessing very high binding affinity and excellent specificity toward complementary RNA or DNA oligonucleotides. The remarkable properties exhibited by LNA oligonucleotides have been employed in different nucleic acid-based therapeutic strategies both in vitro and in vivo. Herein, we highlight the applications of LNA nucleotides for controlling gene expression.
Details
- Title
- Locked nucleic acids: Promising nucleic acid analogs for therapeutic applications
- Authors/Creators
- R.N. Veedu (Author/Creator)J. Wengel (Author/Creator)
- Publication Details
- Chemistry & Biodiversity, Vol.7(3), pp.536-542
- Publisher
- Wiley
- Identifiers
- 991005542841507891
- Copyright
- © 2010 Verlag Helvetica Chimica Acta AG, Zürich
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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Source: InCites
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- Citation topics
- 2 Chemistry
- 2.170 Nucleic Acids Chemistry
- 2.170.988 Oligonucleotide Modifications
- Web Of Science research areas
- Biochemistry & Molecular Biology
- Chemistry, Multidisciplinary
- ESI research areas
- Environment/Ecology