Journal article
Long-term mortality risks associated with mild anaemia in older persons: the Busselton Health Study
Age and Ageing, Vol.41(6), pp.759-764
2012
Abstract
Background: up to 25% of older people in the USA and other Western countries are anaemic by World Health Organization (WHO) criteria. The objective of this study was to examine the long-term relationships of haemoglobin concentration with all-cause and cause-specific mortality in a community-based sample of Australian adults surveyed in 1978. Methods: a community survey of 2,194 adults aged 40+ years in Busselton, Western Australia in 1978 with mortality follow-up to 2001. Cox regression models were used to investigate the relationships of haemoglobin as a continuous measure and anaemia by WHO criteria (women <12 g/dl (7.5 mmol/l); men <13 g/dl (8.1 mmol/l)) with all-cause, cardiovascular and cancer mortality. Results: anaemia was predominantly mild (>10 g/dl) and normocytic. There was an increased risk of death from all causes and from cancer for men with low haemoglobin. Cancers were predominantly of the prostate and genito-urinary organs, and to a lesser extent the gastrointestinal tract. There was no increased risk of all cause or cancer death in women. Conclusion: mild, normocytic anaemia is associated with survival reductions in middle-aged and older men, where it often occurs with prostate, gastrointestinal and other cancers, and should be investigated to exclude treatable causes.
Details
- Title
- Long-term mortality risks associated with mild anaemia in older persons: the Busselton Health Study
- Authors/Creators
- K.A. Chalmers (Author/Creator)M.W. Knuiman (Author/Creator)M.L. Divitini (Author/Creator)D.G. Bruce (Author/Creator)J.K. Olynyk (Author/Creator)E.A. Milward (Author/Creator)
- Publication Details
- Age and Ageing, Vol.41(6), pp.759-764
- Publisher
- Oxford University Press
- Identifiers
- 991005542567607891
- Copyright
- © The Author 2012.
- Murdoch Affiliation
- Institute for Immunology and Infectious Diseases
- Language
- English
- Resource Type
- Journal article
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- 1.184 Physiology & Metals
- 1.184.573 Iron Metabolism
- Web Of Science research areas
- Geriatrics & Gerontology
- ESI research areas
- Clinical Medicine