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Journal article
Longitudinal associations between exercise and biomarkers in autosomal dominant Alzheimer's disease
Alzheimer's & dementia, Vol.20(11), pp.7923-7939
2024
PMID: 39324510
Appears in Open Access via Read & Publish Agreements
Abstract
Introduction
We investigated longitudinal associations between self-reported exercise and Alzheimer's disease (AD)-related biomarkers in individuals with autosomal dominant AD (ADAD) mutations.
Methods
Participants were 308 ADAD mutation carriers aged 39.7 ± 10.8 years from the Dominantly Inherited Alzheimer's Network. Weekly exercise volume was measured via questionnaire and associations with brain volume (magnetic resonance imaging), cerebrospinal fluid biomarkers, and brain amyloid beta (Aβ) measured by positron emission tomography were investigated.
Results
Greater volume of weekly exercise at baseline was associated with slower accumulation of brain Aβ at preclinical disease stages β = –0.16 [–0.23 to –0.08], and a slower decline in multiple brain regions including hippocampal volume β = 0.06 [0.03 to 0.08].
Discussion
Exercise is associated with more favorable profiles of AD-related biomarkers in individuals with ADAD mutations. Exercise may have therapeutic potential for delaying the onset of AD; however, randomized controlled trials are vital to determine a causal relationship before a clinical recommendation of exercise is implemented.
Details
- Title
- Longitudinal associations between exercise and biomarkers in autosomal dominant Alzheimer's disease
- Authors/Creators
- Kelsey R. Sewell - Centre for Healthy Ageing Health Futures Institute, Murdoch University Murdoch Western Australia AustraliaJames D. Doecke - Australian e-Health Research CentreChengjie Xiong - Washington University in St. LouisTammie Benzinger - Washington University in St. LouisColin L. Masters - Florey Institute of Neuroscience and Mental HealthChristoph Laske - German Center for Neurodegenerative DiseasesMathias Jucker - Hertie Institute for Clinical Brain ResearchFrancisco Lopera - Universidad de AntioquiaBrian A. Gordon - Washington University in St. LouisJorge Llibre-Guerra - Alzheimer’s Disease Neuroimaging InitiativeJohannes Levin - Munich Cluster for Systems NeurologyEdward D. Huey - Brown UniversityJason Hassenstab - Washington University in St. LouisPeter R. Schofield - Neuroscience Research AustraliaGregory S. Day - Jacksonville CollegeNick C. Fox - UK Dementia Research InstituteJasmeer Chhatwal - Massachusetts General HospitalLaura Ibanez - Washington University in St. LouisJee Hoon Roh - Korea University Medical CenterRichard Perrin - Washington University in St. LouisJae‐Hong Lee - Asan Medical CenterRicardo F. Allegri - Instituto de Neurología CognitivaCharlene Supnet-Bell - Washington University in St. LouisSarah B. Berman - University of PittsburghAlisha Daniels - Alzheimer’s Disease Neuroimaging InitiativeJames Noble - Columbia UniversityRalph N. Martins - Centre for Healthy Ageing Health Futures Institute, Murdoch University Murdoch Western Australia Australia, Centre of Excellence for Alzheimer's Disease Research and Care School of Medical and Health Sciences Edith Cowan University Joondalup Western Australia Australia, Alzheimer's Research Australia, Ralph and Patricia Sarich Neuroscience Research Institute Nedlands Western Australia Australia, Department of Biomedical Sciences Macquarie University North Ryde New South Wales AustraliaStephanie Rainey-Smith - Murdoch University, Centre for Healthy AgeingJeremiah Peiffer - Murdoch University, Centre for Healthy AgeingSamantha L. Gardener - Edith Cowan UniversityRandall J. Bateman - Washington University in St. LouisJohn C. Morris - Washington University in St. LouisEric McDade - Washington University in St. LouisKirk I. Erickson - University of PittsburghHamid R. Sohrabi - Murdoch University, Centre for Healthy AgeingBelinda M. Brown - Murdoch University, Centre for Healthy AgeingThe Dominantly Inherited Alzheimer's Network
- Publication Details
- Alzheimer's & dementia, Vol.20(11), pp.7923-7939
- Publisher
- Wiley Periodicals LLC on behalf of Alzheimer's Association.
- Number of pages
- 17
- Grant note
- National Institute on Aging: U19AG032438 Alzheimer's Association: SG-20-690363-DIAN, AARFD-21-851415 Korea Dementia Research Center: HU21C0066
Fonds de Recherche du Quebec-Sante; Brain Canada Foundation; Canadian Institute of Health Research; Spanish Institute of Health Carlos III; Korea Health Industry Development Institute; Japan Agency for Medical Research and Development; Deutsches Zentrum fur Neurodegenerative Erkrankungen, Grant/Award Number: N/A; National Institute on Aging, Grant/Award Number: U19AG032438; Alzheimer's Association, Grant/Award Numbers: SG-20-690363-DIAN, AARFD-21-851415; Korea Dementia Research Center, Grant/Award Number: HU21C0066; Raul Carrea Institute for Neurological Research
- Identifiers
- 991005707264307891
- Copyright
- © 2024 The Author(s).
- Murdoch Affiliation
- School of Psychology; Centre for Healthy Ageing
- Language
- English
- Resource Type
- Journal article
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- 1.52 Neurodegenerative Diseases
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