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Published (Version of Record)CC BY-NC V4.0, Open Access
Journal article
Longitudinal associations between self-reported exercise levels and cognition in ADAD
Alzheimer's & dementia, Vol.21(6), e70383
2025
PMID: 40534311
Appears in Open Access via Read & Publish Agreements
Abstract
Introduction
This study examined longitudinal associations between self-reported exercise and cognition, with moderation by sex, in individuals with autosomal dominant Alzheimer's disease (ADAD) mutations. We also examined whether changes in exercise over time differed in ADAD mutation carriers versus non-carriers in the years preceding first cognitive symptom onset.
Methods
Participants (n = 491) were ADAD mutation carriers (63%) and non-carriers (37%) from the Dominantly Inherited Alzheimer Network aged 37.6 ± 11.1 years. Participants reported their average time partaking in various leisure-time exercise activities over the past 12 months.
Results
Greater baseline exercise predicted better longitudinal cognitive performance. Sex did not moderate these associations. In the years preceding first cognitive symptoms or last follow-up visit, mutation carriers showed a decline in their exercise engagement compared to mutation non-carriers.
Discussion
Self-reported exercise is associated with preserved cognitive function in those with ADAD mutations; however, AD-related pathways may influence the level of engagement in exercise prior to cognitive symptom onset.
Highlights
• Greater weekly exercise predicts slower cognitive decline in ADAD mutation carriers.
• These associations varied dependent on closeness to estimated symptom onset.
• These associations were not moderated by sex.
• Weekly exercise declined in ADAD mutation carriers compared to non-carriers.
• Results may suggest a bidirectional relationship between exercise and AD risk.
Details
- Title
- Longitudinal associations between self-reported exercise levels and cognition in ADAD
- Authors/Creators
- Kelsey R Sewell - Murdoch UniversityJames D Doecke - Australian e-Health Research CentreRalph N Martins - Macquarie UniversityStephanie R Rainey-Smith - Edith Cowan UniversityJeremiah Peiffer - Murdoch UniversitySamantha L Gardener - Edith Cowan UniversityHamid R Sohrabi - Murdoch UniversityKirk I Erickson - AdventHealth Research Institute, Neuroscience, Orlando, Florida, USABelinda M Brown - Murdoch UniversityDominantly Inherited Alzheimer Network (DIAN)
- Publication Details
- Alzheimer's & dementia, Vol.21(6), e70383
- Publisher
- Wiley Periodicals LLC on behalf of Alzheimer's Association.
- Grant note
- Deutsches Zentrum für Neurodegenerative Erkrankungen SG-20-690363-DIAN / The Alzheimer's Association Raul Carrea Institute for Neurological Research Instituto de Salud Carlos III Korea Dementia Research Center GNT1197315 / National Health and Medical Research Council (NHMRC) RS-2024-00344521 / Ministry of Health & Welfare and Ministry of Science and ICT, Republic of Korea Japan Agency for Medical Research and Development Korea Health Industry Development Institute N/A / Western Australian Future Health and Innovation Fund, Government of Western Australia
- Identifiers
- 991005787947307891
- Copyright
- © 2025 The Author(s)
- Murdoch Affiliation
- School of Psychology; Research and Innovation Office; Centre for Healthy Ageing; Health Futures Institute
- Language
- English
- Resource Type
- Journal article
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