Journal article
Longitudinal metabolic and gut bacterial profiling of pregnant women with previous bariatric surgery
Gut, Vol.69(8), pp.1452-1459
2020
Abstract
Objective Due to the global increase in obesity rates and success of bariatric surgery in weight reduction, an increasing number of women now present pregnant with a previous bariatric procedure. This study investigates the extent of bariatric-associated metabolic and gut microbial alterations during pregnancy and their impact on fetal development.
Design A parallel metabonomic (molecular phenotyping based on proton nuclear magnetic resonance spectroscopy) and gut bacterial (16S ribosomal RNA gene amplicon sequencing) profiling approach was used to determine maternal longitudinal phenotypes associated with malabsorptive/mixed (n=25) or restrictive (n=16) procedures, compared with women with similar early pregnancy body mass index but without bariatric surgery (n=70). Metabolic profiles of offspring at birth were also analysed.
Results Previous malabsorptive, but not restrictive, procedures induced significant changes in maternal metabolic pathways involving branched-chain and aromatic amino acids with decreased circulation of leucine, isoleucine and isobutyrate, increased excretion of microbial-associated metabolites of protein putrefaction (phenylacetlyglutamine, p-cresol sulfate, indoxyl sulfate and p-hydroxyphenylacetate), and a shift in the gut microbiota. The urinary concentration of phenylacetylglutamine was significantly elevated in malabsorptive patients relative to controls (p=0.001) and was also elevated in urine of neonates born from these mothers (p=0.021). Furthermore, the maternal metabolic changes induced by malabsorptive surgery were associated with reduced maternal insulin resistance and fetal/birth weight.
Conclusion Metabolism is altered in pregnant women with a previous malabsorptive bariatric surgery. These alterations may be beneficial for maternal outcomes, but the effect of elevated levels of phenolic and indolic compounds on fetal and infant health should be investigated further.
Details
- Title
- Longitudinal metabolic and gut bacterial profiling of pregnant women with previous bariatric surgery
- Authors/Creators
- K.A. West (Author/Creator) - Imperial College LondonC. Kanu (Author/Creator) - Chelsea and Westminster HospitalT. Maric (Author/Creator) - Chelsea and Westminster HospitalJ.A.K. McDonald (Author/Creator) - Imperial College LondonJ.K. Nicholson (Author/Creator) - Murdoch UniversityJ.V. Li (Author/Creator) - Imperial College LondonM.R Johnson (Author/Creator)E. Holmes (Author/Creator) - Faculty (United Kingdom)M.D. Savvidou (Author/Creator) - Chelsea and Westminster Hospital
- Publication Details
- Gut, Vol.69(8), pp.1452-1459
- Publisher
- BMJ Publishing Group
- Identifiers
- 991005544719107891
- Copyright
- © 2020 Author(s)
- Murdoch Affiliation
- Australian National Phenome Centre; Health Futures Institute
- Language
- English
- Resource Type
- Journal article
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
Metrics
142 File views/ downloads
26 Record Views
InCites Highlights
These are selected metrics from InCites Benchmarking & Analytics tool, related to this output
- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.120 Inflammatory Bowel Diseases & Infections
- 1.120.384 Gut Microbiota
- Web Of Science research areas
- Gastroenterology & Hepatology
- ESI research areas
- Clinical Medicine