Journal article
Loratadine augments emotional blushing
European Neuropsychopharmacology, Vol.28(11), pp.1284-1288
2018
Abstract
The aim of this study was to determine whether loratadine, a selective inverse agonist of peripheral histamine H1 receptors, would reduce emotional blushing. Loratadine (10 mg) or placebo was administered orally one hour before 31 healthy participants sang a children's nursery rhyme to evoke embarrassment and blushing. Skin blood flow was monitored via a laser Doppler probe attached to the cheek. Increases in facial blood flow while participants sang were greater in the loratadine than the placebo group (mean increase ± standard deviation 71 ± 52% in the loratadine group versus 35 ± 37%, p = .036). However, perceptions of blushing were similar in both groups. These findings suggest that loratadine augmented blushing rather than inhibiting it. Thus, histamine released during blushing may inhibit acute increases in facial blood flow by evoking H1 receptor-mediated vasoconstriction.
Details
- Title
- Loratadine augments emotional blushing
- Authors/Creators
- P.D. Drummond (Author/Creator) - Murdoch UniversityB. Lester (Author/Creator) - Murdoch University
- Publication Details
- European Neuropsychopharmacology, Vol.28(11), pp.1284-1288
- Publisher
- Elsevier
- Identifiers
- 991005540010907891
- Copyright
- © 2018 Elsevier B.V. and ECNP
- Murdoch Affiliation
- School of Psychology and Exercise Science
- Language
- English
- Resource Type
- Journal article
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- Citation topics
- 1 Clinical & Life Sciences
- 1.21 Psychiatry
- 1.21.1949 Social Anxiety
- Web Of Science research areas
- Clinical Neurology
- Neurosciences
- Pharmacology & Pharmacy
- Psychiatry
- ESI research areas
- Neuroscience & Behavior