Low CD4+ T-cell counts in HIV patients receiving effective antiretroviral therapy are associated with CD4+ T-cell activation and senescence but not with lower effector memory T-cell function

S. Fernandez; P. Price; E.J. McKinnon; R.C. Nolan; M.A. French

doi:10.1016/j.clim.2006.04.570

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Low CD4+ T-cell counts in HIV patients receiving effective antiretroviral therapy are associated with CD4+ T-cell activation and senescence but not with lower effector memory T-cell function

Journal article

Peer reviewed

Low CD4+ T-cell counts in HIV patients receiving effective antiretroviral therapy are associated with CD4+ T-cell activation and senescence but not with lower effector memory T-cell function

S. Fernandez, P. Price, E.J. McKinnon, R.C. Nolan and M.A. French

Clinical Immunology, Vol.120(2), pp.163-170

2006

DOI: https://doi.org/10.1016/j.clim.2006.04.570

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Abstract

The adverse effects of immune activation on CD4+ T-cell recovery and the relationship between CD4+ T-cell counts and effector T-cell function were examined in HIV-1 patients receiving long-term effective ART. Patients with nadir CD4+ T-cell counts <100/;Cl, > 12 months on ART and >6 months with <50 HIV RNA copies/ml were stratified by current CD4+ T-cell counts and patients from the lowest (n = 15) and highest (n = 12) tertiles were studied. We assessed proliferation (Ki67), activation (HLA-DR, CD38) and replicative senescence (CD57) by flow cytometry and CD4+ T-cell responses to CMV by IFN-;3 ELISpot. Proportions of CD4+ T-cells expressing HLA-DR or CD57 were strong univariate predictors of total (P = 0.0002 and P = 0.002) and naive (P < 0.0001 and P < 0.0001, respectively) CD4+ T-cell counts, suggesting that CD4+ T-cell activation drives the depletion of naive CD4+ T-cells. This was clearest in patients with a small/undetectable thymus. IFN-;3 responses to CMV were similar in patients with low or high CD4+ T-cell counts.

Details

Title: Low CD4+ T-cell counts in HIV patients receiving effective antiretroviral therapy are associated with CD4+ T-cell activation and senescence but not with lower effector memory T-cell function
Authors/Creators: S. Fernandez (Author/Creator) - Royal Perth Hospital
P. Price (Author/Creator) - Royal Perth Hospital
E.J. McKinnon (Author/Creator) - Murdoch University
R.C. Nolan (Author/Creator) - Royal Perth Hospital
M.A. French (Author/Creator) - Royal Perth Hospital
Publication Details: Clinical Immunology, Vol.120(2), pp.163-170
Publisher: Academic Press Inc.
Identifiers: 991005543624507891
Copyright: 2006 Elsevier Inc.
Murdoch Affiliation: Centre for Clinical Immunology and Biomedical Statistics
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.66 HIV; 1.66.46 HIV Pathogenesis
Web Of Science research areas: Immunology
ESI research areas: Immunology