Journal article
Low calretinin expression and high neutrophil-to-lymphocyte ratio are poor prognostic factors in patients with malignant mesothelioma undergoing extrapleural pneumonectomy
Journal of Thoracic Oncology, Vol.6(11), pp.1923-1929
2011
Abstract
INTRODUCTION:
Survival after extrapleural pneumonectomy (EPP) is variable in patients with malignant pleural mesothelioma (MPM), and there are no validated prognostic factors that could be used preoperatively. We investigated the calretinin and D2-40 expression and the neutrophil-to-lymphocyte ratio (NLR), an index of systemic inflammation as potential preoperative prognostic factors.
METHODS:
Consecutive patients who underwent EPP were included in this retrospective study. Potential prognostic factors such as age, gender, histological subtype, baseline laboratory parameters including NLR, and immunohistochemical staining for calretinin and D2-40 were evaluated. Overall survival (OS) from the date of surgery was determined by the Kaplan-Meier method. The prognostic value of the variables was examined using Cox regression, and significant factors (p < 0.05) were entered into a multivariate model to determine their independent effect.
RESULTS:
A total of 85 patients were included: median age 58 years; 80% men; 77% epithelial and 23% biphasic MPM. The median OS was 19.7 months. The following variables were predictive of longer OS: female gender (p = 0.02), epithelial subtype (p = 0.04), low NLR (p < 0.01), and high calretinin score (p < 0.001). In a multivariate analysis, only NLR ≥3 (hazard ratio 1.79; 95% confidence interval: 1.04-3.07; p = 0.04) and calretinin score ≤33 versus more than 67% (hazard ratio 4.72; 95% confidence interval: 1.97-11.32; p < 0.01) remained independent predictors. The addition of calretinin score increased the explained variation by 10.1%.
CONCLUSIONS:
Both low calretinin expression and high NLR were independently associated with poor prognosis in patients with MPM undergoing EPP, and the calretinin score seemed to improve the accuracy of the prognostic model.
Details
- Title
- Low calretinin expression and high neutrophil-to-lymphocyte ratio are poor prognostic factors in patients with malignant mesothelioma undergoing extrapleural pneumonectomy
- Authors/Creators
- S.C-H Kao (Author/Creator)S. Klebe (Author/Creator) - Flinders Medical CentreD.W. Henderson (Author/Creator) - Flinders Medical CentreG. Reid (Author/Creator) - The University of SydneyM. Chatfield (Author/Creator) - The University of SydneyN.J. Armstrong (Author/Creator) - Garvan Institute of Medical ResearchT.D. Yan (Author/Creator) - Royal Prince Alfred HospitalJ. Vardy (Author/Creator) - Concord Repatriation General HospitalS. Clarke (Author/Creator) - Royal North Shore HospitalN. van Zandwijk (Author/Creator) - The University of SydneyB. McCaughan (Author/Creator) - Royal Prince Alfred Hospital
- Publication Details
- Journal of Thoracic Oncology, Vol.6(11), pp.1923-1929
- Publisher
- Lippincott, Williams & Wilkins
- Identifiers
- 991005543728207891
- Copyright
- 2011 International Association for the Study of Lung Cancer
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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