Journal article
Low-dose oral type I interferons reduce early virus replication of murine cytomegalovirus in vivo
Journal of Interferon & Cytokine Research, Vol.17(10), pp.625-630
1997
Abstract
Immunity to viral infections involves both innate and antigen-specific immune responses. The antiviral properties of interferons (IFNs) are part of the innate immune response. Low doses of type I IFNs (IFN-α and IFN-β) administered daily (10 IU per mouse) by the oral route significantly reduced the early replication of murine cytomegalovirus (MCMV) in both the spleen and liver of MCMV-infected susceptible BALB/c mice. Significant inhibition of virus replication was observed for two different inoculum doses of virus (2 x 104 pfu per mouse [0.6 LD50] and 2 x 104.12 pfu per mouse [0.8 LD50]). Analysis of IFN retention, using [35S]-labeled IFN-α1 compared with the nonreceptor binding mutant IFN-α1 (R33M) administered orally to mice, revealed binding of wild-type IFN-α1 to several tissues. In particular, IFN was retained by tissues proximal to lymphoid regions, including the posterior nasal cavity, posterior tongue, small intestine, and rectum. These findings suggest that type I IFNs may inhibit MCMV replication by distal binding of the orally administered IFN to various tissues, which in turn augment the primary immune response to virus infection.
Details
- Title
- Low-dose oral type I interferons reduce early virus replication of murine cytomegalovirus in vivo
- Authors/Creators
- M.W. Beilharz (Author/Creator)W. McDonald (Author/Creator)M.W. Watson (Author/Creator)J. Heng (Author/Creator)J. McGeachie (Author/Creator)C.M. Lawson (Author/Creator)
- Publication Details
- Journal of Interferon & Cytokine Research, Vol.17(10), pp.625-630
- Publisher
- Mary Ann Liebert Inc.
- Identifiers
- 991005544401307891
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.6 Immunology
- 1.6.106 Interferons
- Web Of Science research areas
- Biochemistry & Molecular Biology
- Cell Biology
- Immunology
- ESI research areas
- Immunology