Journal article
Low-dose oral use of interferon inhibits virally induced myocarditis
Journal of Interferon & Cytokine Research, Vol.19(8), pp.863-867
1999
Abstract
Cytomegalovirus (CMV) infection has been associated with the development of myocarditis in humans. Our established mouse model for CMV myocarditis allows detailed investigation of the immunopathogenic mechanisms and therapies for cardiovascular disease. The type I interferons (IFN-α/β) are part of the innate immune response to CMV infections. Previously, we have reported that daily treatment with low doses of murine IFN-α/β administered by the oral-mucosal route significantly reduces early virus replication of murine CMV in the spleen and liver of infected mice. The oral-mucosal route provides an alternate delivery system to the current modes of IFN administration and is associated with fewer side effects. Since prophylactic treatment with type 1 IFNs may result in both antiviral and immunomodulatory effects that may lessen the development of disease, we wished to study the effect of IFN-α/β on the development of myocarditis. Low-dose oral use of type I IFN (10 IU/day for 7 days prior to virus infection) did not abrogate myocarditis but suppressed the inflammatory response in both the acute and chronic phase of the disease. Furthermore, low-dose oral use of IFN was as effective at inhibiting myocarditis as a single injection of a high dose of IFN (20,000 IU) on the day of virus infection. These findings indicate the need for evaluation of low-dose use of oral IFN in the development of improved clinical therapies for the treatment of cardiovascular disease.
Details
- Title
- Low-dose oral use of interferon inhibits virally induced myocarditis
- Authors/Creators
- C.M. Lawson (Author/Creator) - MicrobiologyM.W. Beilharz (Author/Creator) - School of Pathology and Laboratory Medicine
- Publication Details
- Journal of Interferon & Cytokine Research, Vol.19(8), pp.863-867
- Publisher
- Mary Ann Liebert Inc.
- Identifiers
- 991005544542007891
- Murdoch Affiliation
- School of Veterinary and Biomedical Sciences
- Language
- English
- Resource Type
- Journal article
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
Source: InCites
Metrics
143 File views/ downloads
55 Record Views
InCites Highlights
These are selected metrics from InCites Benchmarking & Analytics tool, related to this output
- Collaboration types
- Domestic collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.161 Virology - Identification & Sequencing
- 1.161.711 Cytomegalovirus Infections
- Web Of Science research areas
- Biochemistry & Molecular Biology
- Cell Biology
- Immunology
- ESI research areas
- Immunology