Low level of systemic autoimmunity in Western Australian multiple sclerosis patients

W. Qiu; C. Bundell; J.-S. Wu; A. Castley; I. James; P. Hollingsworth; F. Christiansen; W.M. Carroll; F.L. Mastaglia; A.G. Kermode

doi:10.1177/1352458509355463

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Low level of systemic autoimmunity in Western Australian multiple sclerosis patients

Journal article

Peer reviewed

Low level of systemic autoimmunity in Western Australian multiple sclerosis patients

W. Qiu, C. Bundell, J.-S. Wu, A. Castley, I. James, P. Hollingsworth, F. Christiansen, W.M. Carroll, F.L. Mastaglia and A.G. Kermode

Multiple Sclerosis, Vol.16(3), pp.351-354

2010

DOI: https://doi.org/10.1177/1352458509355463

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Abstract

Previous autoantibody (AAb) studies in multiple sclerosis MS have produced conflicting results. The objective of this study was to determine AAb frequency and association with the HLA-DRB1 genotype. Antinuclear antibody, antithyroid peroxidase and anti-aquaporin-4 assays and HLA-DRB1 genotyping were performed in 198 MS patients and 188 controls. There were no significant differences in AAb frequency or titres between MS and control subjects. AQP4-IgG was not found in any MS patients. There was no correlation between AAbs and HLA-DRB1 alleles. In conclusion, this study failed to confirm previous reports of increased AAbs in MS or to show an association between HLA-DRB1 genotype and the presence of AAbs.

Details

Title: Low level of systemic autoimmunity in Western Australian multiple sclerosis patients
Authors/Creators: W. Qiu (Author/Creator) - Sun Yat-sen University
C. Bundell (Author/Creator) - Department of Clinical Immunology, PathWest, Queen Elizabeth Medical Centre, Perth, Australia
J.-S. Wu (Author/Creator) - Sir Charles Gairdner Hospital
A. Castley (Author/Creator) - Royal Perth Hospital
I. James (Author/Creator) - Royal Perth Hospital
P. Hollingsworth (Author/Creator) - Department of Clinical Immunology, PathWest, Queen Elizabeth Medical Centre, Perth, Australia
F. Christiansen (Author/Creator) - Royal Perth Hospital
W.M. Carroll (Author/Creator) - Sir Charles Gairdner Hospital
F.L. Mastaglia (Author/Creator) - Sir Charles Gairdner Hospital
A.G. Kermode (Author/Creator) - Sir Charles Gairdner Hospital
Publication Details: Multiple Sclerosis, Vol.16(3), pp.351-354
Publisher: SAGE Publications
Identifiers: 991005546005807891
Copyright: © 2010 The Author(s).
Murdoch Affiliation: Centre for Clinical Immunology and Biomedical Statistics
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.203 Neuromuscular Disorders; 1.203.147 Multiple Sclerosis
Web Of Science research areas: Clinical Neurology; Neurosciences
ESI research areas: Neuroscience & Behavior