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Open Access CC BY V4.0
Journal article
Low von Willebrand factor—unraveling an enigma wrapped in a conundrum
Journal of thrombosis and haemostasis, Vol.22(12), pp.3383-3388
2024
Abstract
The 2021 ASH ISTH NHF WFH guidelines recommendation that patients with VWF levels of 30-50 IU/dL and an increased bleeding phenotype be categorized as type 1 VWD rather than Low VWF has proved controversial. However, in support of that decision, recent data have demonstrated that individuals with partial quantitative VWF deficiency exhibit an age-dependent evolving phenotype and confirmed that Low VWF represents a sub-group within heterogeneous type 1 VWD. Nonetheless, type 1 VWD heterogeneity continues to pose significant diagnostic challenges. In this Forum Article, we address outstanding issues critical to preventing the inappropriate overdiagnosis of type 1 VWD, while maximizing access to healthcare and minimizing diagnostic delays. In addition, we propose an algorithm for type 1 VWD diagnosis. This algorithm pays special attention to individuals with plasma VWF levels in the 30-50 IU/dL range who have no or minimal bleeding history and have not yet been exposed to significant hemostatic challenges.
Details
- Title
- Low von Willebrand factor—unraveling an enigma wrapped in a conundrum
- Authors/Creators
- James S. O’DonnellRoss I. Baker - Murdoch University, Centre for Molecular Medicine and Innovative TherapeuticsFerdows Atiq
- Publication Details
- Journal of thrombosis and haemostasis, Vol.22(12), pp.3383-3388
- Publisher
- Elsevier Inc. on behalf of International Society on Thrombosis and Haemostasis.
- Identifiers
- 991005701566907891
- Copyright
- © 2024 The Authors.
- Murdoch Affiliation
- Murdoch University; Centre for Molecular Medicine and Innovative Therapeutics
- Language
- English
- Resource Type
- Journal article
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