Lower anxiety and a decrease in agonistic behaviour in Lsamp-deficient mice

J. Innos; M-A Philips; E. Leidmaa; I. Heinla; S. Raud; P. Reemann; M. Plaas; K. Nurk; K. Kurrikoff; V. Matto; T. Visnapuu; P. Mardi; S. Kõks; E. Vasar

doi:10.1016/j.bbr.2010.09.019

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Lower anxiety and a decrease in agonistic behaviour in Lsamp-deficient mice

Journal article

Peer reviewed

Lower anxiety and a decrease in agonistic behaviour in Lsamp-deficient mice

J. Innos, M-A Philips, E. Leidmaa, I. Heinla, S. Raud, P. Reemann, M. Plaas, K. Nurk, K. Kurrikoff, V. Matto, …

Behavioural Brain Research, Vol.217(1), pp.21-31

2011

DOI: https://doi.org/10.1016/j.bbr.2010.09.019

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Abstract

In rodents, the Lsamp gene has been implicated in trait anxiety, fear reaction and fear conditioning. Human data link the LSAMP gene to several psychiatric disorders. In this study, we presented a general phenotypic characterization of Lsamp gene-deficient mouse line, created by deleting exon 1b. These mice displayed no gross sensory-motor deficiencies, no overt abnormalities and performed normally in memory and learning tests. However, they responded with increased activity to new environments. Moreover, they displayed reduced anxiety and notable deviations in social behaviour, such as lack of whisker trimming, reduced aggressiveness and reduced dominance. One possible explanation for the anxiolytic-like effect of the deletion of the Lsamp gene is a shift in balance in the Gabra1 and Gabra2 genes in the temporal lobe in favor of the Gabra2 transcript, encoding α2 subunit of GABAA receptors that mediate the stimulating effect of GABA agonists. The overall phenotype of Lsamp-deficient mice, characterized by decreased anxiety and several alterations in social behaviour, makes them a good model for studying the molecular mechanisms behind inadequate social behaviours observed in several psychiatric disorders.

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Title: Lower anxiety and a decrease in agonistic behaviour in Lsamp-deficient mice
Authors/Creators: J. Innos (Author/Creator) - University of Tartu
M-A Philips (Author/Creator) - University of Tartu
E. Leidmaa (Author/Creator) - University of Tartu
I. Heinla (Author/Creator) - University of Tartu
S. Raud (Author/Creator) - University of Tartu
P. Reemann (Author/Creator) - University of Tartu
M. Plaas (Author/Creator) - University of Tartu
K. Nurk (Author/Creator) - University of Tartu
K. Kurrikoff (Author/Creator) - University of Tartu
V. Matto (Author/Creator) - University of Tartu
T. Visnapuu (Author/Creator) - University of Tartu
P. Mardi (Author/Creator) - University of Tartu
S. Kõks (Author/Creator) - University of Tartu
E. Vasar (Author/Creator) - University of Tartu
Publication Details: Behavioural Brain Research, Vol.217(1), pp.21-31
Publisher: Elsevier B.V.
Identifiers: 991005541970707891
Copyright: © 2010 Elsevier B.V.
Murdoch Affiliation: Murdoch University
Language: English
Resource Type: Journal article

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Citation topics: 1 Clinical & Life Sciences; 1.108 Molecular & Cell Biology - Cancer & Development; 1.108.1986 NCAM
Web Of Science research areas: Behavioral Sciences; Neurosciences
ESI research areas: Neuroscience & Behavior