Lung volume recruitment maneuvers and respiratory system mechanics in mechanically ventilated mice

V. Cannizzaro; L.J. Berry; P.K. Nicholls; G.R. Zosk; D.J. Turner; Z. Hantos; P.D. Sly

doi:10.1016/j.resp.2009.09.012

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Lung volume recruitment maneuvers and respiratory system mechanics in mechanically ventilated mice

Journal article

Open access

Peer reviewed

Lung volume recruitment maneuvers and respiratory system mechanics in mechanically ventilated mice

V. Cannizzaro, L.J. Berry, P.K. Nicholls, G.R. Zosk, D.J. Turner, Z. Hantos and P.D. Sly

Respiratory Physiology & Neurobiology, Vol.169(3), pp.243-251

2009

DOI: https://doi.org/10.1016/j.resp.2009.09.012

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Abstract

The study aim was to establish how recruitment maneuvers (RMs) influence lung mechanics and to determine whether RMs produce lung injury. Healthy BALB/c mice were allocated to receive positive end-expiratory pressure (PEEP) at 2 or 6 cmH2O and volume- (20 or 40 mL/kg) or pressure-controlled (25 cmH2O) RMs every 5 or 75 min for 150 min. The low-frequency forced oscillation technique was used to measure respiratory input impedance. Large RMs resulting in peak airway opening pressures (Pao) > 30 cmH2O did not increase inflammatory response or affect transcutaneous oxygen saturation but significantly lowered airway resistance, tissue damping and tissue elastance; the latter changes are likely associated with the bimodal pressure-volume behavior observed in mice. PEEP increase alone and application of RMs producing peak Pao below 25 cmH2O did not prevent or reverse changes in lung mechanics; whereas frequent application of substantial RMs on top of elevated PEEP levels produced stable lung mechanics without signs of lung injury.

Details

Title: Lung volume recruitment maneuvers and respiratory system mechanics in mechanically ventilated mice
Authors/Creators: V. Cannizzaro (Author/Creator) - The Kids Research Institute Australia
L.J. Berry (Author/Creator) - The Kids Research Institute Australia
P.K. Nicholls (Author/Creator) - Murdoch University
G.R. Zosk (Author/Creator)
D.J. Turner (Author/Creator) - The Kids Research Institute Australia
Z. Hantos (Author/Creator) - University of Szeged
P.D. Sly (Author/Creator) - The Kids Research Institute Australia
Publication Details: Respiratory Physiology & Neurobiology, Vol.169(3), pp.243-251
Publisher: Elsevier
Identifiers: 991005543012107891
Copyright: 2009 Elsevier B.V
Murdoch Affiliation: School of Veterinary and Biomedical Sciences
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.154 Assisted Ventilation; 1.154.277 Mechanical Ventilation
Web Of Science research areas: Physiology; Respiratory System
ESI research areas: Clinical Medicine