MEIS proteins as partners of the TLX1/HOX11 oncoprotein

N. Milech; N.G. Gottardo; J. Ford; D. D'Souza; W.K. Greene; U.R. Kees; P.M. Watt

doi:10.1016/j.leukres.2009.06.003

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MEIS proteins as partners of the TLX1/HOX11 oncoprotein

Journal article

Open access

Peer reviewed

MEIS proteins as partners of the TLX1/HOX11 oncoprotein

N. Milech, N.G. Gottardo, J. Ford, D. D'Souza, W.K. Greene, U.R. Kees and P.M. Watt

Leukemia Research, Vol.34(3), pp.358-363

2010

DOI: https://doi.org/10.1016/j.leukres.2009.06.003

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Abstract

Aberrant expression of the TLX1/. HOX11 proto-oncogene is associated with a significant subset of T-cell acute lymphoblastic leukemias (T-ALL). Yet the manner in which TLX1 contributes to oncogenesis is not fully understood. Since, typically, interactions of HOX and TALE homeodomain proteins are determinant of HOX function, and HOX/MEIS co-expression has been shown to accelerate some leukemias, we systematically examined whether TLX1 interacts with MEIS and PBX proteins. Here, we report that TLX1 and MEIS proteins both interact and are co-expressed in T-ALL, and suggest that co-operation between TLX1 and MEIS proteins may have a significant role in T-cell leukemogenesis.

Details

Title: MEIS proteins as partners of the TLX1/HOX11 oncoprotein
Authors/Creators: N. Milech (Author/Creator) - The Kids Research Institute Australia
N.G. Gottardo (Author/Creator) - The Kids Research Institute Australia
J. Ford (Author/Creator) - The Kids Research Institute Australia
D. D'Souza (Author/Creator) - The Kids Research Institute Australia
W.K. Greene (Author/Creator) - Murdoch University
U.R. Kees (Author/Creator) - The Kids Research Institute Australia
P.M. Watt (Author/Creator) - The Kids Research Institute Australia
Publication Details: Leukemia Research, Vol.34(3), pp.358-363
Publisher: Elsevier BV
Identifiers: 991005539583107891
Copyright: © 2009 Elsevier Ltd.
Murdoch Affiliation: School of Veterinary and Biomedical Sciences
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.108 Molecular & Cell Biology - Cancer & Development; 1.108.207 Neural Crest
Web Of Science research areas: Hematology; Oncology
ESI research areas: Clinical Medicine