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Magnetic resonance imaging in Leber's optic neuropathy
Journal article   Peer reviewed

Magnetic resonance imaging in Leber's optic neuropathy

A.G. Kermode, I.F. Moseley, B.E. Kendall, D.H. Miller, D.G. Macmanus and W.I. McDonald
Journal of Neurology, Neurosurgery & Psychiatry, Vol.52(5), pp.671-674
1989
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Abstract

Thirteen males with Leber's optic neuropathy had magnetic resonance imaging (MRI) of the brain, and in eight the optic nerves were imaged using STIR (Short Time Inversion Recovery) sequences. All optic nerve scans were abnormal. In seven with bilateral visual loss four showed bilateral increased optic nerve signal and three unilateral increase. The involvement was of the mid and posterior intra-orbital sections over three 5 mm slices or more with sparing of the anterior portion. One patient with unilateral visual loss had increased signal only on the affected side. Brain MRI was normal, in marked contrast to the findings in clinically isolated optic neuritis in which multiple white matter lesions are seen in the majority.

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Citation topics
1 Clinical & Life Sciences
1.197 Molecular & Cell Biology - Mitochondria
1.197.564 Mitochondrial Function
Web Of Science research areas
Clinical Neurology
Psychiatry
Surgery
ESI research areas
Clinical Medicine
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