Journal article
Major differences in the dynamics of primary and secondary progressive multiple sclerosis
Annals of Neurology, Vol.29(1), pp.53-62
1991
Abstract
In patients with primary and secondary progressive multiple sclerosis (MS), major differences in the pattern and extent of abnormality on cerebral magnetic resonance imaging (MRI) between the two groups have recently been demonstrated. In the present study, 24 patients, matched for age, sex, duration of disease, and disability, had serial gadolinium diethylenetriaminepentaacetic acid–enhanced MRI over a 6-month period. The 12 patients in the secondary progressive group had a total of 109 new lesions over this time (18.2 lesions per patient per year) and 87% of these enhanced. Enhancement also occurred within and at the edge of preexisting lesions. In contrast, only 20 new lesions were seen in the primary progressive group (3.3 lesions per patient per year) and only one of these enhanced. There was no difference in the degree of clinical deterioration between the two groups over the 6-month period. These findings may indicate a difference in the dynamics of disease activity between the two forms of progressive MS, particularly in relation to the inflammatory component of the lesions, and have important implications for the selection of patients and the monitoring of disease activity in therapeutic trials.
Details
- Title
- Major differences in the dynamics of primary and secondary progressive multiple sclerosis
- Authors/Creators
- A.J. Thompson (Author/Creator) - Multiple Sclerosis NMR Research Group, Institute of Neurology, London, Great Britain.A.G. Kermode (Author/Creator) - National Hospital for Neurology and NeurosurgeryD. Wicks (Author/Creator) - National Hospital for Neurology and NeurosurgeryD.G. MacManus (Author/Creator) - National Hospital for Neurology and NeurosurgeryB.E. Kendall (Author/Creator) - National Hospital for Neurology and NeurosurgeryD.P.E. Kingsley (Author/Creator) - National Hospital for Neurology and NeurosurgeryW.I. McDonald (Author/Creator) - National Hospital for Neurology and Neurosurgery
- Publication Details
- Annals of Neurology, Vol.29(1), pp.53-62
- Publisher
- Wiley
- Identifiers
- 991005546336807891
- Copyright
- © 1991 American Neurological Association
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- Citation topics
- 1 Clinical & Life Sciences
- 1.203 Neuromuscular Disorders
- 1.203.147 Multiple Sclerosis
- Web Of Science research areas
- Clinical Neurology
- Neurosciences
- ESI research areas
- Neuroscience & Behavior