Journal article
Major histocompatibility complex class II alleles and haplotypes associated with non-suppurative meningoencephalitis in greyhounds
Tissue Antigens, Vol.84(3), pp.271-276
2014
Abstract
Non-suppurative meningoencephalitis is a breed-restricted canine neuroinflammatory disorder affecting young greyhounds in Ireland. A genetic risk factor is suspected because of the development of disease in multiple siblings and an inability to identify a causative infectious agent. The aim of this study was to examine potential associations between dog leucocyte antigen (DLA) class II haplotype and the presence of the disease. DLA three locus haplotypes were determined in 31 dogs with non-suppurative meningoencephalitis and in 115 healthy control dogs using sequence-based typing (SBT) methods. All dogs were unrelated at the parental level. Two haplotypes (DRB1*01802/DQA1*00101/DQB1*00802 and DRB1*01501/DQA1*00601/DQB1*02201) were significantly (P=0.0099 and 0.037) associated with the presence of meningoencephalitis, with odds ratios (95% confidence interval) of 5.531 (1.168-26.19) and 3.736 (1.446-9.652), respectively. These results confirm that there is an association between DLA class II haplotype and greyhound meningoencephalitis, suggesting an immunogenetic risk factor for the development of the disease. Greyhound meningoencephalitis may be a suitable model for human neuroinflammatory diseases with an immunogenetic component.
Details
- Title
- Major histocompatibility complex class II alleles and haplotypes associated with non-suppurative meningoencephalitis in greyhounds
- Authors/Creators
- R.E. Shiel (Author/Creator)L.J. Kennedy (Author/Creator)C.M. Nolan (Author/Creator)C.T. Mooney (Author/Creator)J.J. Callanan (Author/Creator)
- Publication Details
- Tissue Antigens, Vol.84(3), pp.271-276
- Publisher
- Blackwell Publishing
- Identifiers
- 991005544594907891
- Copyright
- © 2014 John Wiley and Sons A/S.
- Murdoch Affiliation
- School of Veterinary and Life Sciences
- Language
- English
- Resource Type
- Journal article
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- Citation topics
- 1 Clinical & Life Sciences
- 1.6 Immunology
- 1.6.607 MHC Diversity
- Web Of Science research areas
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- Immunology
- Pathology
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- Molecular Biology & Genetics