Journal article
Mannoside storage and axonal dystrophy in sensory neurones of swainsonine-treated rats: Morphogenesis of lesions
Acta Neuropathologica, Vol.68(1), pp.65-73
1985
Abstract
Young rats were treated with swainsonine for up to 200 days at a dose rate that restricted neuronal mannoside storage to neurones not protected by the blood/brain barrier. In lumbar dorsal root ganglion neurones, mannoside storage in the cell body developed in parallel to dystrophic changes at the extremities of peripherally and centrally directed axons. The dystrophic process involved the accumulation of autophagic structures. In the CNS, axonal dystrophy was confined to areas receiving long processes from affected neurones. The results suggest that axonal dystrophy is a direct consequence of the lysosomal storage process in parent cell bodies. The possible relationship of axonal dystrophy to neuronal lysosomal function is discussed.
Details
- Title
- Mannoside storage and axonal dystrophy in sensory neurones of swainsonine-treated rats: Morphogenesis of lesions
- Authors/Creators
- C.R. Huxtable (Author/Creator)P.R. Dorling (Author/Creator)
- Publication Details
- Acta Neuropathologica, Vol.68(1), pp.65-73
- Publisher
- Springer-Verlag
- Identifiers
- 991005543860807891
- Copyright
- © 1985 Springer-Verlag.
- Murdoch Affiliation
- School of Veterinary Studies
- Language
- English
- Resource Type
- Journal article
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
Source: InCites
Metrics
44 Record Views
InCites Highlights
These are selected metrics from InCites Benchmarking & Analytics tool, related to this output
- Citation topics
- 2 Chemistry
- 2.1 Synthesis
- 2.1.1145 Iminosugar Synthesis
- Web Of Science research areas
- Clinical Neurology
- Neurosciences
- Pathology
- ESI research areas
- Neuroscience & Behavior