Mapping of a candidate region for susceptibility to inclusion body myositis in the human major histocompatibility complex

C.C. Kok; E.J. Croager; C.S. Witt; L. Kiers; F.L. Mastaglia; L.J. Abraham; M.J. Garlepp

doi:10.1007/s002510050528

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Mapping of a candidate region for susceptibility to inclusion body myositis in the human major histocompatibility complex

Journal article

Peer reviewed

Mapping of a candidate region for susceptibility to inclusion body myositis in the human major histocompatibility complex

C.C. Kok, E.J. Croager, C.S. Witt, L. Kiers, F.L. Mastaglia, L.J. Abraham and M.J. Garlepp

Immunogenetics, Vol.49(6), pp.508-516

1999

DOI: https://doi.org/10.1007/s002510050528

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Abstract

Inclusion body myositis (IBM) is a form of idiopathic inflammatory myopathy of unknown aetiology. A strong association with HLA class II (HLA-DR3) suggested a role for genes in the human major histocompatibility complex (MHC) in the predisposition to this disease. In this study, we have taken advantage of the ancestral haplotype (AH) concept and historical recombinations to map for a possible susceptibility gene(s) in the MHC. We performed detailed typing of three MHC-related HSP70 genes and defined allelic combinations in the context of MHC AH. We also modified existing methods to give a simple and accurate method for typing two TNF microsatellites. Using the HSP70 and TNF markers and HLA-DR, –B, and C4 typing of our patients with IBM, we defined a potential site for the MHC-associated susceptibility gene(s) in the region between HLA-DR and C4.

Details

Title: Mapping of a candidate region for susceptibility to inclusion body myositis in the human major histocompatibility complex
Authors/Creators: C.C. Kok (Author/Creator) - Queen Elizabeth II Medical Centre
E.J. Croager (Author/Creator) - The University of Western Australia
C.S. Witt (Author/Creator) - Royal Perth Hospital
L. Kiers (Author/Creator) - The Royal Melbourne Hospital
F.L. Mastaglia (Author/Creator) - Queen Elizabeth II Medical Centre
L.J. Abraham (Author/Creator) - The University of Western Australia
M.J. Garlepp (Author/Creator) - Curtin University
Publication Details: Immunogenetics, Vol.49(6), pp.508-516
Publisher: Springer-Verlag
Identifiers: 991005541285007891
Copyright: 1999 Springer-Verlag
Murdoch Affiliation: Murdoch University
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.106 Rheumatology; 1.106.1684 Dermatomyositis
Web Of Science research areas: Genetics & Heredity; Immunology
ESI research areas: Immunology