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CC BY V4.0, Open Access
Journal article
Maternal Fiber Dietary Intakes during Pregnancy and Infant Allergic Disease
Nutrients, Vol.11(8), 1767
2024
Abstract
Maternal diet during pregnancy plays a likely role in infant immune development through both direct nutrient specific immunomodulatory effects and by modulating the composition and metabolic activity of the maternal gut microbiome. Dietary fibers, as major substrates for microbial fermentation, are of interest in this context. This is the first study to examine maternal intakes of different fiber sub-types and subsequent infant allergic disease. In an observational study of 639 mother–infant pairs (all infants had a family history of allergic disease) we examined maternal intakes of total fiber, soluble fiber, insoluble fiber, resistant starch, and prebiotic fiber, by a semi-quantitative food frequency questionnaire at 36–40 weeks’ gestation. Infants attended an allergy clinical assessment at 12 months of age, including skin prick testing to common allergens. Higher maternal dietary intakes of resistant starch were associated with reduced doctor diagnosed infant wheeze, adjusted odds ratio (aOR) 0.68 (95% CI 0.49, 0.95, p = 0.02). However, in contrast, higher maternal intakes of resistant starch were associated with higher risk of parent reported eczema aOR 1.27 (95% CI 1.09, 1.49, p < 0.01) and doctor diagnosed eczema aOR 1.19 (95% CI 1.01, 1.41, p = 0.04). In conclusion, maternal resistant starch consumption was differentially associated with infant phenotypes, with reduced risk of infant wheeze, but increased risk of eczema.
Details
- Title
- Maternal Fiber Dietary Intakes during Pregnancy and Infant Allergic Disease
- Authors/Creators
- Rachelle Ann Pretorius (Author) - Murdoch University, School of Medical, Molecular and Forensic Sciences
- Publication Details
- Nutrients, Vol.11(8), 1767
- Publisher
- MDPI
- Number of pages
- 14
- Grant note
- National Health and Medical Research Council (NHMRC) of Australia: APP1002381, APP1046036 NHMRC: APP1144544, APP572503
This research was funded by the National Health and Medical Research Council (NHMRC) of Australia: Project Grants (APP1002381 and APP1046036) and NHMRC Fellowships for D.J.P. APP1144544 and S.L.P. APP572503. R.A.P. is funded by an Australian Postgraduate Award and Safety Net Top-up scholarship from the University of Western Australia. The publication fee for this manuscript was funded by the Telethon Kids Institute Fellowship Support Allowance for D.J.P.
- Identifiers
- 991005703870107891
- Copyright
- © 2019 by the authors.
- Murdoch Affiliation
- School of Medical, Molecular and Forensic Sciences
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
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- Citation topics
- 1 Clinical & Life Sciences
- 1.120 Inflammatory Bowel Diseases & Infections
- 1.120.384 Gut Microbiota
- Web Of Science research areas
- Nutrition & Dietetics
- ESI research areas
- Agricultural Sciences