Maternal dietary intervention during lactation impacts the maternal faecal and human milk microbiota

Azhar S Sindi; Lisa F Stinson; Zoya Gridneva; Gabriela E Leghi; Merryn J Netting; Mary E Wlodek; Beverly S Muhlhausler; Alethea Rea; Michelle L Trevenen; Donna T Geddes; Matthew S Payne

doi:10.1093/jambio/lxae024

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Maternal dietary intervention during lactation impacts the maternal faecal and human milk microbiota

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Maternal dietary intervention during lactation impacts the maternal faecal and human milk microbiota

Azhar S Sindi, Lisa F Stinson, Zoya Gridneva, Gabriela E Leghi, Merryn J Netting, Mary E Wlodek, Beverly S Muhlhausler, Alethea Rea, Michelle L Trevenen, Donna T Geddes, …

Journal of applied microbiology, Vol.135(5), lxae024

2024

DOI: https://doi.org/10.1093/jambio/lxae024

PMID: 38323424

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Abstract

breastfeeding

maternal faecal microbiome

human milk microbiome

Maternal diet

To determine the effect of a two-week reduced fat and sugar and increased fibre maternal dietary intervention on the maternal faecal and human milk (HM) microbiomes. Faecal swabs and HM samples were collected from mothers (n = 11) immediately pre-intervention, immediately post-intervention, and 4- and 8-weeks post-intervention, and were analysed using full-length 16S rRNA gene sequencing. Maternal macronutrient intake was assessed at baseline and during the intervention. Maternal fat and sugar intake during the intervention were significantly lower than pre-intervention (P=<0.001, 0.005, respectively). Significant changes in the bacterial composition of maternal faeces were detected after the dietary intervention, with decreases in the relative abundance of Bacteroides caccae (P=<0.001) and increases in the relative abundance of Faecalibacillus intestinalis (P = 0.006). In HM, the diet resulted in a significant increase in Cutibacterium acnes (P = 0.001) and a decrease in Haemophilus parainfluenzae (P=<0.001). The effect of the diet continued after the intervention, with faecal swabs and HM samples taken 4- and 8-weeks after the diet showing significant differences compared to baseline. This pilot study demonstrates that short-term changes in maternal diet during lactation can alter the bacterial composition of the maternal faeces and HM. Clinical trial registration: Australian New Zealand Clinical Trials Registry (ACTRN12619000606189). Website: https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=377188&isReview=true.

Details

Title: Maternal dietary intervention during lactation impacts the maternal faecal and human milk microbiota
Authors/Creators: Azhar S Sindi - The University of Western Australia
Lisa F Stinson - Community Arts Network
Zoya Gridneva - The University of Western Australia
Gabriela E Leghi - The University of Adelaide
Merryn J Netting - South Australian Health and Medical Research Institute
Mary E Wlodek - The University of Western Australia
Beverly S Muhlhausler - The University of Adelaide
Alethea Rea - Murdoch University, Centre for Terrestrial Ecosystem Science and Sustainability
Michelle L Trevenen - The University of Western Australia
Donna T Geddes - The University of Western Australia
Matthew S Payne - The University of Western Australia
Publication Details: Journal of applied microbiology, Vol.135(5), lxae024
Publisher: Oxford University Press on behalf of Applied Microbiology International.
Identifiers: 991005656369907891
Murdoch Affiliation: School of Mathematics, Statistics, Chemistry and Physics
Language: English
Resource Type: Journal article

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