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Journal article
Maternal oxidative stress during pregnancy associated with emotional and behavioural problems in early childhood: implications for foetal programming
Molecular psychiatry, Vol.28, pp.3760-3768
2023
PMID: 37845496
Abstract
Childhood mental disorders, including emotional and behavioural problems (EBP) are increasingly prevalent. Higher maternal oxidative stress (OS) during pregnancy (matOSpreg) is linked to offspring mental disorders. Environmental factors contribute to matOSpreg. However, the role of matOSpreg in childhood EBP is unclear. We investigated the associations between (i) matOSpreg and offspring EBP; (ii) social and prenatal environmental factors and matOSpreg; and (iii) social and prenatal factors and childhood EBP and evaluated whether matOSpreg mediated these associations. Maternal urinary OS biomarkers, 8-hydroxyguanosine (8-OHGua; an oxidative RNA damage marker) and 8-hydroxy-2 ' -deoxyguanosine (8-OHdG; an oxidative DNA damage marker), at 36 weeks of pregnancy were quantified by liquid chromatography-mass spectrometry in a population-derived birth cohort, Barwon Infant Study (n = 1074 mother-infant pairs). Social and prenatal environmental factors were collected by mother-reported questionnaires. Offspring total EBP was measured by Child Behavior Checklist Total Problems T-scores at age two (n = 675) and Strengths and Difficulties Questionnaire Total Difficulties score at age four (n = 791). Prospective associations were examined by multivariable regression analyses adjusted for covariates. Mediation effects were evaluated using counterfactual-based mediation analysis. Higher maternal urinary 8-OHGua at 36 weeks ((mat)8-OHGua(36w)) was associated with greater offspring total EBP at age four (beta = 0.38, 95% CI (0.07, 0.69), P = 0.02) and age two (beta = 0.62, 95% CI (-0.06, 1.30), P = 0.07). Weaker evidence of association was detected for 8-OHdG. Five early-life factors were associated with both (mat)8-OHGua(36w) and childhood EBP (P-range < 0.001-0.05), including lower maternal education, socioeconomic disadvantage and prenatal tobacco smoking. These risk factor-childhood EBP associations were partly mediated by higher (mat)8-OHGua(36w) (P-range = 0.01-0.05). Higher matOSpreg, particularly oxidant RNA damage, is associated with later offspring EBP. Effects of some social and prenatal lifestyle factors on childhood EBP were partly mediated by matOSpreg. Future studies are warranted to further elucidate the role of early-life oxidant damage in childhood EBP.
Details
- Title
- Maternal oxidative stress during pregnancy associated with emotional and behavioural problems in early childhood: implications for foetal programming
- Authors/Creators
- Cindy Pham - Florey Institute of Neuroscience and Mental HealthSarah Thomson - The University of MelbourneSung-Tong Chin - Murdoch University, School of Medical, Molecular and Forensic SciencesPeter Vuillermin - Barwon HealthMartin O'Hely - Deakin UniversityDavid Burgner - The University of Western AustraliaSamuel Tanner - Florey Institute of Neuroscience and Mental HealthRichard Saffery - The University of MelbourneToby Mansell - The University of MelbourneSze Bong - Murdoch UniversityElaine Holmes - University of LondonPeter D. Sly - The University of QueenslandNicola Gray - Murdoch University, Centre for Computational and Systems MedicineAnne-Louise Ponsonby - Univ Melbourne, Royal Childrens Hosp, Murdoch Childrens Res Inst, Parkville, VIC 3052, AustraliaBarwon Infant Study Invest GrpBarwon Infant Study Investigator Group
- Publication Details
- Molecular psychiatry, Vol.28, pp.3760-3768
- Publisher
- Springer Nature
- Number of pages
- 9
- Grant note
- Scobie Trust GMHBA Limited Minderoo Foundation NHMRC, Australia Investigator Grants; National Health and Medical Research Council (NHMRC) of Australia Shepherd Foundation Murdoch Children's Research Institute, Deakin University Percy Baxter Charitable Trust Jack Brockhoff Foundation The authors thank the Barwon Infant Study participants for their valuable contribution. The establishment work and infrastructure for the BIS was provided by the Murdoch Children's Research Institute, Deakin University and Barwon Health. S Rotary Club of Geelong Shane O'Brien Memorial Asthma Foundation Ilhan Food Allergy Foundation Our Women's Our Children's FundRaising Committee Barwon Health 2018-984 / Victorian Government's Operational Infrastructure Support Programme Cotton On Foundation APP1197234 / Melbourne Children's Campus LifeCourse PhD Support Programme scholarship - Royal Children's Hospital Foundation National Health and Medical Research Council of Australia; National Health and Medical Research Council (NHMRC) of Australia
- Identifiers
- 991005613370307891
- Copyright
- © 2023 The Author(s)
- Murdoch Affiliation
- Australian National Phenome Centre; Centre for Computational and Systems Medicine; School of Medical, Molecular and Forensic Sciences
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.152 Molecular & Cell Biology - DNA Damage
- 1.152.251 Nucleotide Excision Repair
- Web Of Science research areas
- Biochemistry & Molecular Biology
- Neurosciences
- Psychiatry
- ESI research areas
- Neuroscience & Behavior