Journal article
Mechanisms of hypervirulent Clostridium difficile ribotype 027 displacement of endemic strains: an epidemiological model
Scientific Reports, Vol.5, Article 12666
2015
Abstract
Following rapid, global clonal dominance of hypervirulent ribotypes, Clostridium difficile now constitutes the primary infectious cause of nosocomial diarrhoea. Evidence indicates at least three possible mechanisms of hypervirulence that facilitates the successful invasion of these atypical strains: 1) increased infectiousness relative to endemic strains; 2) increased symptomatic disease rate relative to endemic strains; and 3) an ability to outcompete endemic strains in the host's gut. Stochastic simulations of an infection transmission model demonstrate clear differences between the invasion potentials of C. difficile strains utilising the alternative hypervirulence mechanisms, and provide new evidence that favours certain mechanisms (1 and 2) more than others (3). Additionally, simulations illustrate that direct competition between strains (inside the host's gut) is not a prerequisite for the sudden switching that has been observed in prevailing ribotypes; previously dominant C. difficile strains can be excluded by hypervirulent ribotypes through indirect (exploitative) competition.
Details
- Title
- Mechanisms of hypervirulent Clostridium difficile ribotype 027 displacement of endemic strains: an epidemiological model
- Authors/Creators
- L. Yakob (Author/Creator) - Department of Disease ControlT.V. Riley (Author/Creator) - Queen Elizabeth II Medical CentreD.L. Paterson (Author/Creator) - The University of QueenslandJ. Marquess (Author/Creator) - Queensland HealthR.J.S. Magalhaes (Author/Creator) - Children's Medical Research InstituteL. Furuya-Kanamori (Author/Creator) - Australian National UniversityA.C.A. Clements (Author/Creator) - Australian National University
- Publication Details
- Scientific Reports, Vol.5, Article 12666
- Publisher
- Nature Publishing Group
- Identifiers
- 991005541369807891
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- 1 Clinical & Life Sciences
- 1.120 Inflammatory Bowel Diseases & Infections
- 1.120.1133 Clostridium Infections
- Web Of Science research areas
- Microbiology
- ESI research areas
- Clinical Medicine