Medicinal plants as a source of antiparasitics: an overview of experimental studies

Sandamalie Ranasinghe; Anthony Armson; Alan J. Lymbery; Alireza Zahedi; Amanda Ash

doi:10.1080/20477724.2023.2179454

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Medicinal plants as a source of antiparasitics: an overview of experimental studies

Journal article

Peer reviewed

Medicinal plants as a source of antiparasitics: an overview of experimental studies

Sandamalie Ranasinghe, Anthony Armson, Alan J. Lymbery, Alireza Zahedi and Amanda Ash

Pathogens and global health, Vol.ahead-of-print(ahead-of-print)

2023

DOI: https://doi.org/10.1080/20477724.2023.2179454

PMID: 36805662

Appears in Open Access via Read & Publish Agreements

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Abstract

Antiparasitic

gastrointestinal parasites

natural medicine

parasitic drug resistance

plant compounds

Despite advances in modern human and veterinary medicine, gastrointestinal (GI) parasitic infections remain a significant health issue worldwide, mainly in developing countries. Increasing evidence of the multi-drug resistance of these parasites and the side effects of currently available synthetic drugs have led to increased research on alternative medicines to treat parasitic infections. The exploration of potential botanical antiparasitics, which are inexpensive and abundant, may be a promising alternative in this context. This study summarizes the in vitro/in vivo antiparasitic efficacy of different medicinal plants and their components against GI parasites. Published literature from 1990-2020 was retrieved from Google Scholar, Web of Science, PubMed and Scopus. A total of 68 plant species belonging to 32 families have been evaluated as antiparasitic agents against GI parasites worldwide. The majority of studies (70%) were conducted in vitro. Most plants were from the Fabaceae family (53%, n = 18). Methanol (37%, n = 35) was the most used solvent. Leaf (22%, n = 16) was the most used plant part, followed by seed and rhizome (each 12%, n = 9). These studies suggest that herbal medicines hold a great scope for new drug discoveries against parasitic diseases and that the derivatives of these plants are useful structures for drug synthesis and bioactivity optimization.

Details

Title: Medicinal plants as a source of antiparasitics: an overview of experimental studies
Authors/Creators: Sandamalie Ranasinghe - Murdoch University
Anthony Armson - Murdoch University
Alan J. Lymbery - Murdoch University
Alireza Zahedi - Murdoch University
Amanda Ash - Murdoch University
Publication Details: Pathogens and global health, Vol.ahead-of-print(ahead-of-print)
Publisher: Taylor & Francis
Identifiers: 991005578586207891
Murdoch Affiliation: Centre for Biosecurity and One Health; School of Environmental and Conservation Sciences; Centre for Sustainable Aquatic Ecosystems; School of Medical, Molecular and Forensic Sciences
Language: English
Resource Type: Journal article

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Citation topics: 1 Clinical & Life Sciences; 1.163 Parasitology - General; 1.163.1022 Anthelmintic Resistance
Web Of Science research areas: Parasitology; Public, Environmental & Occupational Health; Tropical Medicine
ESI research areas: Clinical Medicine