Melanocytes in the Skin – Comparative Whole Transcriptome Analysis of Main Skin Cell Types

P. Reemann; E. Reimann; S. Ilmjärv; O. Porosaar; H. Silm; V. Jaks; E. Vasar; K. Kingo; S. Kõks

doi:10.1371/journal.pone.0115717

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Melanocytes in the Skin – Comparative Whole Transcriptome Analysis of Main Skin Cell Types

Journal article

Open access

Peer reviewed

Melanocytes in the Skin – Comparative Whole Transcriptome Analysis of Main Skin Cell Types

P. Reemann, E. Reimann, S. Ilmjärv, O. Porosaar, H. Silm, V. Jaks, E. Vasar, K. Kingo and S. Kõks

PLoS ONE, Vol.9(12)

2014

DOI: https://doi.org/10.1371/journal.pone.0115717

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Abstract

Melanocytes possess several functions besides a role in pigment synthesis, but detailed characteristics of the cells are still unclear. We used whole transcriptome sequencing (RNA-Seq) to assess differential gene expression of cultivated normal human melanocytes with respect to keratinocytes, fibroblasts and whole skin. The present results reveal cultivated melanocytes as highly proliferative cells with possible stem cell-like properties. The enhanced readiness to regenerate makes melanocytes the most vulnerable cells in the skin and explains their high risk of developing into malignant melanoma.

Details

Title: Melanocytes in the Skin – Comparative Whole Transcriptome Analysis of Main Skin Cell Types
Authors/Creators: P. Reemann (Author/Creator) - University of Tartu
E. Reimann (Author/Creator) - University of Tartu
S. Ilmjärv (Author/Creator) - University of Tartu
O. Porosaar (Author/Creator) - Tallinn Health Care College
H. Silm (Author/Creator) - Tartu University Hospital
V. Jaks (Author/Creator) - University of Tartu
E. Vasar (Author/Creator) - University of Tartu
K. Kingo (Author/Creator) - Tartu University Hospital
S. Kõks (Author/Creator) - University of Tartu
Publication Details: PLoS ONE, Vol.9(12)
Publisher: Public Library of Science
Identifiers: 991005546027307891
Copyright: 2014 Reemann et al.
Murdoch Affiliation: Murdoch University
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.158 Dermatology - General; 1.158.918 Melanogenesis Mechanisms
Web Of Science research areas: Oncology
ESI research areas: Molecular Biology & Genetics