Journal article
Memory Inflation Drives Tissue-Resident Memory CD8+ T Cell Maintenance in the Lung After Intranasal Vaccination With Murine Cytomegalovirus
Frontiers in Immunology, Vol.9
2018
Abstract
Tissue-resident memory T (TRM) cells provide first-line defense against invading pathogens encountered at barrier sites. In the lungs, TRM cells protect against respiratory infections, but wane more quickly than TRM cells in other tissues. This lack of a sustained TRM population in the lung parenchyma explains, at least in part, why infections with some pathogens, such as influenza virus and respiratory syncytial virus (RSV), recur throughout life. Intranasal (IN) vaccination with a murine cytomegalovirus (MCMV) vector expressing the M protein of RSV (MCMV-M) has been shown to elicit robust populations of CD8+ TRM cells that accumulate over time and mediate early viral clearance. To extend this finding, we compared the inflationary CD8+ T cell population elicited by MCMV-M vaccination with a conventional CD8+ T cell population elicited by an MCMV vector expressing the M2 protein of RSV (MCMV-M2). Vaccination with MCMV-M2 induced a population of M2-specific CD8+ TRM cells that waned rapidly, akin to the M2-specific CD8+ TRM cell population elicited by infection with RSV. In contrast to the natural immunodominance profile, however, coadministration of MCMV-M and MCMV-M2 did not suppress the M-specific CD8+ T cell response, suggesting that progressive expansion was driven by continuous antigen presentation, irrespective of the competitive or regulatory effects of M2-specific CD8+ T cells. Moreover, effective viral clearance mediated by M-specific CD8+ TRM cells was not affected by the coinduction of M2-specific CD8+ T cells. These data show that memory inflation is required for the maintenance of CD8+ TRM cells in the lungs after IN vaccination with MCMV.
Details
- Title
- Memory Inflation Drives Tissue-Resident Memory CD8+ T Cell Maintenance in the Lung After Intranasal Vaccination With Murine Cytomegalovirus
- Authors/Creators
- K.M. Morabito (Author/Creator) - National Institute of Allergy and Infectious DiseasesT.J. Ruckwardt (Author/Creator) - National Institute of Allergy and Infectious DiseasesE. Bar-Haim (Author/Creator) - Israel Institute for Biological ResearchD. Nair (Author/Creator) - National Institute of Allergy and Infectious DiseasesS.M. Moin (Author/Creator) - National Institute of Allergy and Infectious DiseasesA.J. Redwood (Author/Creator) - Murdoch UniversityD.A. Price (Author/Creator) - Cardiff UniversityB.S. Graham (Author/Creator) - National Institute of Allergy and Infectious Diseases
- Publication Details
- Frontiers in Immunology, Vol.9
- Publisher
- Frontiers Media
- Identifiers
- 991005544283807891
- Copyright
- © 2018 Morabito, Ruckwardt, Bar-Haim, Nair, Moin, Redwood, Price and Graham.
- Murdoch Affiliation
- Institute for Immunology and Infectious Diseases
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.161 Virology - Identification & Sequencing
- 1.161.711 Cytomegalovirus Infections
- Web Of Science research areas
- Immunology
- ESI research areas
- Immunology