Journal article
Mesothelial cells and peritoneal homeostasis
Fertility and Sterility, Vol.106(5), pp.1018-1024
2016
Abstract
The mesothelium was traditionally thought to be a simple tissue with the sole function of providing a slippery, nonadhesive, and protective surface to allow easy movement of organs within their body cavities. However, our knowledge of mesothelial cell physiology is rapidly expanding, and the mesothelium is now recognized as a dynamic cellular membrane with many other important functions. When injured, mesothelial cells initiate a cascade of processes leading either to complete regeneration of the mesothelium or the development of pathologies such as adhesions. Normal mesothelial healing is unique in that, unlike with other epithelial-like surfaces, healing appears diffusely across the denuded surface, whereas for epithelium healing occurs solely at the wound edges. This is because of a free-floating population of mesothelial cells which attach to the injured serosa. Taking advantage of this phenomenon, intraperitoneal injections of mesothelial cells have been assessed for their ability to prevent adhesion formation. This review discusses some of the functions of mesothelial cells regarding maintenance of serosal integrity and outlines the mechanisms involved in mesothelial healing. In addition, the pathogenesis of adhesion formation is discussed with particular attention to the potential role of mesothelial cells in both preventing and inducing their development.
Details
- Title
- Mesothelial cells and peritoneal homeostasis
- Authors/Creators
- S.E. Mutsaers (Author/Creator)C.M. Prêle (Author/Creator)S. Pengelly (Author/Creator)S.E. Herrick (Author/Creator)
- Publication Details
- Fertility and Sterility, Vol.106(5), pp.1018-1024
- Publisher
- Elsevier
- Identifiers
- 991005544680707891
- Copyright
- ©2016 Published by Elsevier Inc.
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
Source: InCites
Metrics
48 Record Views
InCites Highlights
These are selected metrics from InCites Benchmarking & Analytics tool, related to this output
- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.216 Abdominal Surgery
- 1.216.1563 Intestinal Obstruction
- Web Of Science research areas
- Obstetrics & Gynecology
- Reproductive Biology
- ESI research areas
- Clinical Medicine