Journal article
Mesothelial cells in tissue repair and fibrosis
Frontiers in Pharmacology, Vol.6, Art. 00113
2015
Abstract
Mesothelial cells are fundamental to the maintenance of serosal integrity and homeostasis and play a critical role in normal serosal repair following injury. However, when normal repair mechanisms breakdown, mesothelial cells take on a profibrotic role, secreting inflammatory, and profibrotic mediators, differentiating and migrating into the injured tissues where they contribute to fibrogenesis. The development of new molecular and cell tracking techniques has made it possible to examine the origin of fibrotic cells within damaged tissues and to elucidate the roles they play in inflammation and fibrosis. In addition to secreting proinflammatory mediators and contributing to both coagulation and fibrinolysis, mesothelial cells undergo mesothelial-to-mesenchymal transition, a process analogous to epithelial-to-mesenchymal transition, and become fibrogenic cells. Fibrogenic mesothelial cells have now been identified in tissues where they have not previously been thought to occur, such as within the parenchyma of the fibrotic lung. These findings show a direct role for mesothelial cells in fibrogenesis and open therapeutic strategies to prevent or reverse the fibrotic process.
Details
- Title
- Mesothelial cells in tissue repair and fibrosis
- Authors/Creators
- S.E. Mutsaers (Author/Creator) - The University of Western AustraliaK. Birnie (Author/Creator) - The University of Western AustraliaS. Lansley (Author/Creator) - The University of Western AustraliaS.E. Herrick (Author/Creator) - Manchester Academic Health Science CentreC-B Lim (Author/Creator) - Harry Perkins Institute of Medical ResearchC.M. Prêle (Author/Creator) - Harry Perkins Institute of Medical Research
- Publication Details
- Frontiers in Pharmacology, Vol.6, Art. 00113
- Publisher
- Frontiers Media S.A.
- Identifiers
- 991005544769207891
- Copyright
- © 2015 Mutsaers et al.
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
Source: InCites
Metrics
46 File views/ downloads
58 Record Views
InCites Highlights
These are selected metrics from InCites Benchmarking & Analytics tool, related to this output
- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.55 Urology & Nephrology - General
- 1.55.299 Dialysis Modalities
- Web Of Science research areas
- Pharmacology & Pharmacy
- ESI research areas
- Pharmacology & Toxicology