Journal article
Mesothelial cells regulate immune responses in health and disease: Role for immunotherapy in malignant mesothelioma
Current Opinion in Immunology, Vol.64, pp.88-109
2020
Abstract
The mesothelium when first described was thought to function purely as a non-adhesive surface to facilitate intracoelomic movement of organs. However, the mesothelium is now recognized as a dynamic cellular membrane with many important functions that maintain serosal integrity and homeostasis. For example, mesothelial cells interact with and help regulate the body’s inflammatory and immune system following infection, injury, or malignancy. With recent advances in our understanding of checkpoint molecules and the advent of novel immunotherapy approaches, there has been an increase in the number of studies examining mesothelial and immune cell interaction, in particular the role of these interactions in malignant mesothelioma. This review will highlight some of the recent advances in our understanding of how mesothelial cells help regulate serosal immunity and how in a malignant environment, the immune system is hijacked to stimulate tumor growth. Ways to treat mesothelioma using immunotherapy approaches will also be discussed.
Details
- Title
- Mesothelial cells regulate immune responses in health and disease: Role for immunotherapy in malignant mesothelioma
- Authors/Creators
- S.E Mutsaers (Author/Creator) - The University of Western AustraliaF.J. Pixley (Author/Creator) - The University of Western AustraliaC.M. Prêle (Author/Creator) - The University of Western AustraliaG.F. Hoyne (Author/Creator) - The University of Notre Dame Australia
- Publication Details
- Current Opinion in Immunology, Vol.64, pp.88-109
- Publisher
- Elsevier
- Identifiers
- 991005541502207891
- Copyright
- © 2020 Elsevier Ltd.
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.297 Asbestos & Mesothelioma
- 1.297.780 Asbestos-Mesothelioma Link
- Web Of Science research areas
- Immunology
- ESI research areas
- Immunology